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Diet and nutrition

Olive Oil and Olive Leaf — A Mediterranean Secret to a Healthy Heart?

Sources: 17 · Article: 25 968 characters

It also describes its use for wounds, burns, dry skin, and some skin conditions.

  • According to Henryk Różański, olive leaf is said to lower blood pressure and blood sugar levels and support blood vessels.
  • Henryk Różański also lists anti-inflammatory, anti-atherosclerotic, and antimicrobial effects of the leaves.
  • Henryk Różański warns that, in people with gallstones, olive oil may move a stone and trigger colic.

What the authors write

Henryk Różański

Olive oil is said to stimulate bile secretion, coat the digestive tract, reduce stomach acid secretion, and have a laxative effect.

„In margarines, it is hydrogenated in the presence of catalysts, transforming into stearic acid (a saturated fatty acid). Olive oil taken by mouth at a dose of 200 g per day has a bile-stimulating and bile-producing effect, coats the walls of the digestive tract, reduces the amount of hydrochloric acid secreted in the stomach, and loosens the bowels.”W margarynach podlega redukcji wodorem w obecności katalizatorów, przekształcając się w kwas stearynowy (kwas tłuszczowy nasycony). Oliwa podawana doustnie w dawce 200 g dziennie działa żółciopędnie i żółciotwórczo, powleka ściany przewodu pokarmowego, zmniejsza ilość wydzielanego kwasu solnego w żołądku, rozwalnia.
Olej z oliwek – Oleum Olivae jak lek, pokarm i kosmetyk
Henryk Różański

Olive oil is said to reduce inflammation, bloating, and constipation, and to support the healing of stomach ulcers.

„It reduces inflammation, prevents bile stasis and the formation of gallstones. It reduces bloating and speeds up the healing of stomach ulcers. In the past, olive oil was used medicinally to treat and prevent bile stasis, gallstones, peptic ulcers, intestinal catarrh, bloating, and constipation; and as a detoxifying agent.”Zmniejsza stany zapalne, zapobiega zastojom żółci i powstawaniu kamicy żółciowej. Zmniejsza wzdęcia, przyspiesza gojenie wrzodów żołądka. Dawniej w lecznictwie stosowano oliwę w leczeniu i profilaktyce zastojów żółci, kamicy żółciowej, choroby wrzodowej, nieżytów jelit, bębnicy, zaparcia; jako sodek odtruwający.
Olej z oliwek – Oleum Olivae jak lek, pokarm i kosmetyk
Henryk Różański

Applied to the skin, olive oil is said to support the healing of wounds and burns, moisturize the skin, and ease the symptoms of psoriasis and acne.

„For external use, especially green and cloudy olive oil is used to treat wounds and burns, prevent dry skin and dry dermatitis, and ease the symptoms of psoriasis and, paradoxically, acne, although acne is often associated with oily skin. Olive oil taken by mouth and applied to the skin at the same time reduces keratinization of the epidermis and sebaceous glands, prevents hair follicles from becoming blocked, softens, moisturizes, and nourishes the skin, and restores the normal, desired composition of sebum.”Zewnętrznie, szczególnie zielona i mętna oliwa z oliwek leczy rany, oparzenia, zapobiega suchości skóry, suchemu zapaleniu skóry, łagodzi objawy łuszczycy i paradoksalnie łagodzi objawy trądziku, choć ten często jest na podłożu łojotoku. Oliwa spożywana doustnie i stosowana na skórę jednocześnie zmniejsza rogowacenie naskórka i gruczołów łojowych, zapobiega powstawaniu niedrożności mieszków włosowych, rozmiękcza skórę, natłuszcza ją i odżywia, przywraca prawidłowy i pożądany skład łoju.
Olej z oliwek – Oleum Olivae jak lek, pokarm i kosmetyk
Henryk Różański

Regular consumption of olive oil is said to reduce allergy symptoms and cholesterol levels, and to have anti-atherosclerotic and antidiabetic effects.

„Regularly taking olive oil reduces symptoms of various allergies, increases the body's resistance to infections, lowers blood cholesterol, slows the development of atherosclerosis, has antidiabetic effects, and stimulates the regeneration of epithelial tissue. It has a beneficial effect in people with an enlarged prostate gland.”Oliwa zażywana regularnie zmniejsza objawy rozmaitych alergii, podnosi odporność organizmu na infekcje, zmniejsza poziom cholesterolu we krwi, hamuje rozwój miażdżycy, działa przeciwcukrzycowo, pobudza regenerację tkanki nabłonkowej. Korzystnie działa u chorych na przerost gruczołu krokowego.
Olej z oliwek – Oleum Olivae jak lek, pokarm i kosmetyk
Henryk Różański

Olive oil mixed with cod liver oil is said to be used on hard-to-heal wounds, burns, frostbite, and chafing.

„It has a beneficial effect in people with an enlarged prostate gland. Unheated olive oil helps treat eczema and atopic dermatitis; when used in warm compresses and mixed with cod liver oil in a 1:1 ratio, it also helps treat abscesses. Mixed with cod liver oil, it is excellent for treating hard-to-heal wounds and burns, frostbite, and chafing.”Korzystnie działa u chorych na przerost gruczołu krokowego. Oliwa surowa pomaga w leczeniu wyprysków, atopowego zapalenia skóry, a w ciepłych okładach i po wymieszaniu z tranem 1:1 również ropni. Wymieszana z tranem doskonale leczy trudno gojące się rany i oparzenia, odmrożenia, odparzenia.
Olej z oliwek – Oleum Olivae jak lek, pokarm i kosmetyk
Henryk Różański

Olive oil hair baths are said to help with scalp psoriasis, hair loss, dryness, and brittleness.

„Olive oil hair baths are recommended for scalp psoriasis, hair loss, dry and brittle hair, and split ends. Olive oil mixed with cod liver oil in a 1:1 ratio is a valuable conditioner and restorative for the skin and hair, especially when they have been damaged by various procedures or after poisoning.”Kąpiele oliwne dla włosów są polecane w łuszczycy owłosionej skóry głowy, przy wypadaniu, suchości i łamliwości włosów, ponadto przy rozdwajaniu końców włosów. Oliwa wymieszana z tranem 1:1 to cenna odżywka i czynnik regenerujący dla skóry i włosów, szczególnie uszkodzonych różnymi zabiegami i po zatruciach.
Olej z oliwek – Oleum Olivae jak lek, pokarm i kosmetyk
Henryk Różański

Olive oil is said to prevent bile stasis and small deposits from clumping together, but it does not dissolve large stones.

„Olive oil does not break down large gallstones. By increasing the flow of bile, it may only help push sand and small deposits out of the biliary system. It prevents bile stasis and small stones and particles of sand from clumping together. In addition, by changing the composition of bile (as a lipotropic agent that lowers cholesterol and supplies unsaturated fatty acids), it may reduce the risk of, and thus the process of, bile precipitates clustering (aggregating).”Olej oliwkowy nie powoduje rozpad dużych kamieni żółciowych. Może powodować jedynie przepchnięcie piasku i drobnych złogów z układu żółciowego poprzez zwiększenie strumienia żółci. Zapobiega zastojom i zlepianiu się drobnych kamyczków i piasku. Ponadto przez zmianę składu jakościowego żółci (jako czynnik lipotropowy, obniżający poziom cholesterolu, dostarczający kwasy tłuszczowe nienasycone) może zmniejszać ryzyko i tym samym proces konglomeracji (agregacji) strątów żółci.
Olej z oliwek – Oleum Olivae jak lek, pokarm i kosmetyk
Henryk Różański

In people with gallstones, olive oil may move a gallstone and cause colic.

„It should be remembered that taking olive oil when you have gallstones may move a gallstone and cause it to become stuck, triggering biliary colic. Olive oil does not break down large gallstones. By increasing the flow of bile, it may only help push sand and small deposits out of the biliary system.”Należy pamiętać, że oliwa spożywana przy kamicy może spowodować przemieszczenie kamienia żółciowego i jego zastój, co spowoduje kolkę żółciową. Olej oliwkowy nie powoduje rozpad dużych kamieni żółciowych. Może powodować jedynie przepchnięcie piasku i drobnych złogów z układu żółciowego poprzez zwiększenie strumienia żółci.
Olej z oliwek – Oleum Olivae jak lek, pokarm i kosmetyk
Henryk Różański

Olive leaf extracts are said to widen the coronary arteries, lower blood pressure and glucose levels, and have anti-atherosclerotic effects.

„Extracts from olive tree leaves widen the coronary arteries, lower blood pressure, and have anti-atherosclerotic, anti-arrhythmic, and antispasmodic effects. They lower blood glucose levels. Tinctures are more effective because their active compounds are difficult to dissolve in water.”Wyciągi z liści drzewa oliwnego rozszerzają naczynia wieńcowe, obniżają ciśnienie krwi, działają przeciwmiażdżycowo, antyarytmicznie i spazmolitycznie. Obniżają poziom glukozy we krwi. Nalewki są bardziej efektywne ze względu na trudno rozpuszczalne związki czynne w wodzie.
Liść drzewa oliwnego – Folium Oleae w fitoterapii
Henryk Różański

Olive leaf preparations are said to lower blood pressure and blood glucose levels and widen the coronary arteries.

„Olive leaf preparations lower blood pressure, widen the coronary arteries, and reduce blood glucose levels. Ethanol tinctures (1:10, 70% ethanol) are more pharmacologically effective because their active compounds are difficult to dissolve.”Preparaty z liści oliwnych obniżają ciśnienie tętnicze, rozszerzają naczynia wieńcowe i zmniejszają poziom glukozy we krwi. Nalewki etanolowe (1:10, 70% etanol) są bardziej efektywne farmakologicznie ze względu na trudno rozpuszczalne związki czynne.
Leki przeciwcukrzycowe. Grupa VIII: inhibitory dipeptydylopeptydazy-4 (DPP-4).
Henryk Różański

Olive leaf oleuropein is said to have anti-atherosclerotic, vasodilating, anti-arrhythmic, and antispasmodic effects.

„Oleacein and related secoiridoids show angiotensin-converting enzyme inhibitor (ACEI) activity, while oleuropein is responsible for anti-atherosclerotic, vasodilating, anti-arrhythmic, and antispasmodic effects. Numerous studies also confirm blood-glucose-lowering effects, partly due to DPP-4 inhibition and increased AMPK-dependent glucose metabolism in muscles.”Oleaceina i pokrewne sekoirydoidy wykazują aktywność inhibitorów konwertazy angiotensyny (ACEI), natomiast oleuropeina odpowiada za działanie przeciwmiażdżycowe, wazodylatacyjne, antyarytmiczne i spazmolityczne. Liczne badania potwierdzają również działanie hipoglikemizujące, częściowo wynikające z hamowania DPP‑4 oraz nasilenia zależnej od AMPK przemiany glukozy w mięśniach.
Leki przeciwcukrzycowe. Grupa VIII: inhibitory dipeptydylopeptydazy-4 (DPP-4).
Henryk Różański

Olive leaves are said to have antidiabetic, anti-inflammatory, antibacterial, antiviral, and antiparasitic effects.

„Phytopharmacological effects: antidiabetic, anti-atherosclerotic, anti-platelet aggregation, improved coronary blood flow, lower blood pressure in hypertension, cytotoxic effects against cancer cells, antiparasitic, anti-inflammatory, antioxidant, protective effects on the heart muscle; antiviral, fungistatic, antibacterial, and immune-stimulating.”Działanie fitofarmakologiczne: przeciwcukrzycowe, przeciwmiażdżycowe, antyagregacyjne na płytki krwi, poprawiające przepływ wieńcowy, obniżające ciśnienie krwi przy nadciśnieniu, cytotoksyczne wobec komórek nowotworowych, antypasożytnicze, przeciwzapalne, antyoksydacyjne, ochronne na mięsień sercowy; przeciwwirusowe, fungistatyczne, antybakteryjne; immunostymulujące.
Folium Oleae – liść drzewa oliwnego (Oliwki europejskiej) – Olea europaea L. w fitoterapii.
Henryk Różański

Olive leaf tincture is described as a wash for eczema and bacterial skin conditions, and as a compress for wounds and burns.

„Tincture: 1 part fresh or dried leaves to 5 parts 45–50% alcohol; macerate for at least 1 week. Take 5 ml 2–3 times a day. It can also be used externally to wash eczema and bacterial skin conditions, and in compresses for hard-to-heal wounds, ulcers, burns, and pressure sores.”Nalewka – tinctura: 1 część świeżych lub suchych liści na 5 części alkoholu 45-50%; macerować minimum 1 tydzień; zażywać 2-3 razy dziennie po 5 ml, ponadto stosować zewnętrznie do przemywania wyprysków i schorzeń bakteryjnych, do okładów na trudno gojące się rany, owrzodzenia, oparzenia, odleżyny.
Folium Oleae – liść drzewa oliwnego (Oliwki europejskiej) – Olea europaea L. w fitoterapii.
Henryk Różański

Olive leaf is listed as an ingredient in an anticancer mixture, but this passage does not explain the effects of the leaf itself.

„Anticancer mixture Crushed olive leaf: 1 part by volume Celandine herb: 1 part Tansy herb: 1 part Iceland moss: 1 part Herb of mourning or stinking cranesbill: 1 part Stinking horehound herb or lapacho bark: 1 part Mix the crushed herbs thoroughly.”Mieszanka przeciwnowotworowa Liść oliwki rozdrobnione: 1 część objętościowa Ziele glistnika: 1 cz. Ziele wrotyczu 1 cz. Płucnica islandzka 1 cz. Ziele bodziszka żałobnego lub cuchnącego 1 cz. Ziele mierznicy lub kora lapacho 1 cz. Zioła rozdrobnione wymieszać starannie.
Folium Oleae – liść drzewa oliwnego (Oliwki europejskiej) – Olea europaea L. w fitoterapii.
Henryk Różański

According to Henryk Różański, olive oil with grated turnip is said to stimulate bile flow and help remove small deposits.

„Grated turnip with olive oil is a strong bile-stimulating and detoxifying agent. It produces a strong flow of bile that may flush small gall deposits out of the biliary system. It also helps eliminate many unnecessary and harmful xenobiotics and metabolites, thereby having a detoxifying effect on the liver.”Rzepa tarta z oliwą z oliwek jest silnym środkiem żółciopędnym i odtruwającym; wytwarza silny strumień żółci, który może wypłukiwać z układu żółciowego drobne złogi żółciowe. Ponadto przyczynia się do wydalenia wielu ksenobiotyków i metabolitów zbędnych oraz szkodliwych, przez co wpływa odtruwająco na wątrobę.
Czarna rzepa – Raphanus sativus niger i Raphacholin

Research from PubMed · Europe PMC

We selected 9 studies with the best, positive results. This is a selection, not a full review of all research.

Total number of studies on this topic in PubMed: 74.

The review points to an association between olive oil consumption and better outcomes in atherosclerosis and some cardiometabolic diseases.

Aim of the study: The Mediterranean diet is often associated with longevity and a lower incidence of adverse cardiovascular events because of the biological activity and health effects of olives, its key component. Olive oil, olive leaf extract, fruits, and various by-products contain many bioactive components with antioxidant, anti-inflammatory, and anti-apoptotic effects.

Results: Olive oil, olive leaf extract, fruits, and various by-products contain many bioactive components with antioxidant, anti-inflammatory, and anti-apoptotic effects. This review focuses on recent studies examining the molecular mechanisms behind the heart-protective properties of different olive oils, olive leaf extracts, and specific minor components (such as oleuropein, tyrosol, hydroxytyrosol, and others) in laboratory studies, rodent models, and clinical trials involving people. In particular, hydroxytyrosol and oleuropein were identified as the main bioactive compounds responsible for the antioxidant, anti-inflammatory, anti-platelet aggregation, and anti-atherogenic effects of olive oil. Overall, the results discussed showed a positive association between olive oil consumption and improved outcomes in atherosclerosis, diabetes, myocardial infarction, heart failure, hypertension, and obesity.

Use of Olives-derived Phytochemicals for Prevention and Treatment of Atherosclerosis: An Update. · Curr Top Med Chem 2024
Money for the studygovernment, public institutions · Russian Science Foundation
Do the authors have ties to companies?not stated
Did a manufacturer help with the study?unknown
Type of studydiscussion of other studies

“Not stated” does not mean nobody paid — the database does not always record it.

In a mouse model of Alzheimer's disease, olive leaf extract reduced inflammatory changes in the brain and improved memory.

Aim of the study: Alzheimer's disease (AD) is the most common form of dementia among several neurodegenerative disorders affecting older people. AD is characterized by the buildup of extracellular amyloid-β (Aβ) plaques, a disrupted blood-brain barrier (BBB), and neuroinflammation.

Results: Mice were fed an OLE-enriched diet (695 μg/kg body weight/day) for 3 months, starting at 3 months of age. Overall, the findings showed that OLE reduced neuroinflammation by inhibiting the NF-κB pathway and suppressing the activation of NLRP3 inflammasomes and the RAGE/HMGB1 pathways. In addition, OLE reduced total Aβ levels in the brain by increasing its clearance and reducing its production. It also improved the integrity and function of the BBB. Together, these effects improved memory. Thus, taking OLE as a dietary supplement is expected to stop and/or slow the progression of AD.

Oleuropein-Rich Olive Leaf Extract Attenuates Neuroinflammation in the Alzheimer's Disease Mouse Model. · ACS Chem Neurosci 2022
Money for the studycompany or manufacturer · Boundary Bend Olives Pty, Australia
Do the authors have ties to companies?not stated
Did a manufacturer help with the study?YES
Type of studyanimal study

“Not stated” does not mean nobody paid — the database does not always record it.

In a small pilot study of healthy volunteers, red blood cell counts and hemoglobin levels increased after 8 weeks of taking the extract.

Aim of the study: Natural products have recently received considerable attention as complementary or alternative agents for treating anemia. In this regard, olive leaf extract, which is rich in bioactive phenolic compounds, has been reported to induce red blood cell development in human hematopoietic stem cells.

Results: After 8 weeks of taking WOL, red blood cell counts and hemoglobin levels increased significantly. Notably, there were no significant changes in safety measures related to liver and kidney function. We also identified oleuropein and oleuroside as the active components in WOL that induce red blood cell development in the K562 cell line. Overall, our study provides evidence of WOL's potential to support blood formation in living organisms, opening up promising possibilities for future use in preventing or treating anemia.

Hematinic Potential of Olive Leaf Extract: Evidence from an In Vivo Study in Mice and a Pilot Study in Healthy Human Volunteers. · Nutrients 2023
Money for the studygovernment, public institutions · Japan Science and Technology Agency, Science and Technology Research Partnership for Sustainable Development
Do the authors have ties to companies?yes — the authors reported it
Did a manufacturer help with the study?YES
Type of studyanimal study

“Not stated” does not mean nobody paid — the database does not always record it.

In rats, olive oil and olive leaf extract reduced liver damage caused by fluoxetine.

Aim of the study: Olive oil and olive leaf extract have several health benefits; however, their protective effects against fluoxetine-induced liver injury have not been investigated. This study aimed to examine the impact of fluoxetine on rat livers and evaluate the protective effects of olive oil and olive leaf extract.

Results: Taking olive oil and olive leaf extract together significantly reduced circulating liver-function marker enzymes and pro-inflammatory cytokines, and prevented fluoxetine-induced changes in tissue structure. Both olive oil and leaf extract significantly reduced lipid peroxidation and nitric oxide in the liver, and improved levels of glutathione, superoxide dismutase, catalase, and glutathione peroxidase. In addition, olive oil and leaf extract prevented fluoxetine-induced apoptosis in rat livers, as shown by reduced expression of Bax and caspase-3 and increased expression of Bcl-2. In conclusion, olive oil and leaf extract protect against fluoxetine-induced liver injury in rats by reducing oxidative stress, inflammation, and apoptosis.

Olive oil and leaf extract prevent fluoxetine-induced hepatotoxicity by attenuating oxidative stress, inflammation and apoptosis. · Biomed Pharmacother 2018
Money for the studyuniversity or foundation · Olive Research Center, Deanship, Aljouf University
Do the authors have ties to companies?not stated
Did a manufacturer help with the study?unknown
Type of studyanimal study

“Not stated” does not mean nobody paid — the database does not always record it.

A review of animal studies found that olive derivatives stimulated thyroid function in animals with normal or reduced thyroid function.

Aim of the study: Olive oil, commonly used in the Mediterranean diet, is known for health benefits related to a reduced risk of cancer, coronary heart disease, hypertension, and neurodegenerative disease. These unique properties are attributed to the phytochemicals in olive oil, which have strong antioxidant effects.

Results: Despite the positive results, the beneficial health effects of olive derivatives have not been confirmed in people. In conclusion, olive derivatives, especially olive oil and leaf extract, may stimulate thyroid function. Olive pomace residue is not suitable for pharmaceutical or dietary supplement use. The therapeutic use of olive oil and leaf extract, especially in people with hypothyroidism, requires further confirmation through studies in humans.

Thyroid-Modulating Activities of Olive and Its Polyphenols: A Systematic Review. · Nutrients 2021
Money for the studyuniversity or foundation · Universiti Kebangsaan Malaysia
Do the authors have ties to companies?no — the authors say so
Did a manufacturer help with the study?NO
Type of studyreview of many studies

“Not stated” does not mean nobody paid — the database does not always record it.

The review describes possible effects of olive polyphenols in reducing inflammation and oxidative stress associated with damage to the nervous system.

Aim of the study: Neurological diseases such as stroke and multiple sclerosis are associated with high rates of illness and death, long-term disability, and social and economic costs. They therefore pose a major challenge for medical treatment.

Results: Polyphenols from olive oil, especially extra virgin olive oil, olive leaves, olive leaf extract, and other olive tree derivatives, reduce inflammation and oxidative stress, two major factors in demyelination. They also reduce the risk of stroke through several effects, including anti-atherosclerotic, blood-pressure-lowering, antioxidant, anti-inflammatory, cholesterol-lowering, blood-glucose-lowering, and anti-thrombotic effects. Olive polyphenols also benefit blood lipid profiles and insulin sensitivity in people with obesity. This review provides an updated account of the beneficial properties and mechanisms of action of olive polyphenols against demyelination, in the prevention or mitigation of multiple sclerosis—the most common non-traumatic neurological cause of disability in younger adults—and against brain injury, which is becoming more common and has already reached epidemic proportions.

Neuroprotective Panel of Olive Polyphenols: Mechanisms of Action, Anti-Demyelination, and Anti-Stroke Properties. · Nutrients 2022
Money for the studyuniversity or foundation · University of Rijeka
Do the authors have ties to companies?no — the authors say so
Did a manufacturer help with the study?NO
Type of studydiscussion of other studies

“Not stated” does not mean nobody paid — the database does not always record it.

In laboratory studies, oleuropein and olive leaf extract inhibited the growth of the bacteria tested.

Aim of the study: Although synthetic preservatives and antioxidants may have strong antimicrobial and antioxidant effects, they are usually associated with adverse effects on human health. There is currently growing interest in natural antimicrobial and antioxidant agents. This study aimed to evaluate the antimicrobial activity of two medicinal plant extracts and one active compound.

Results: Oleuropein showed complete antimicrobial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. In this context, a 7-log reduction was achieved during the storage period (4 weeks). Oleuropein showed no antifungal activity at low concentrations (0.2%), but reduced Aspergillus niger by 2.35 logs at higher concentrations (0.6% w/v). Similar antibacterial and antifungal properties were observed for olive leaf extracts. Oleuropein at a concentration of 0.4 w/v and a mixture of oleuropein and thyme at concentrations of 0.4 and 0.1 (v/v) showed strong antimicrobial activity against the microorganisms studied. Olive leaf extract, thyme oil, and oleuropein have strong antibacterial and weak antifungal properties. Oleuropein and thymol also showed good synergistic effects.

Evaluation of the antibacterial and antifungal properties of oleuropein, olea Europea leaf extract, and thymus vulgaris oil. · BMC Complement Med Ther 2024
Money for the studynot stated
Do the authors have ties to companies?no — the authors say so
Did a manufacturer help with the study?NO
Type of studylaboratory study (on cells)

“Not stated” does not mean nobody paid — the database does not always record it.

In a laboratory study, enriching an olive oil extract with olive leaf extract improved its antioxidant and anti-inflammatory properties.

Aim of the study: (1) Background: The health-promoting properties of extra virgin olive oil (EVOO), including its antioxidant and anti-inflammatory effects, are now well recognized and are mainly attributed to its various polyphenols, such as oleocanthal and oleacein. In EVOO production, olive leaves are a valuable by-product. They show a broad range of beneficial effects because they contain polyphenols, especially oleuropein.

Results: For further biological testing, an EVOO extract enriched with 8% OLE was selected. Its antioxidant effects were evaluated using three different methods (DPPH, ABTS, and FRAP), and its anti-inflammatory properties were assessed by measuring the inhibition of cyclooxygenase activity. (3) Results: The antioxidant and anti-inflammatory profiles of the new EVOO/OLE extract were significantly improved compared with those of the EVOO extract. (4) Conclusions: Combining OLE and EVOO extract can produce an extract enriched in bioactive polyphenols with better biological properties than EVOO extract alone. It may therefore be a new supplement in the nutraceutical field.

Enhanced Nutraceutical Properties of Extra Virgin Olive Oil Extract by Olive Leaf Enrichment. · Nutrients 2023
Money for the studygovernment, public institutions · University of Pisa, Ministry of University and Research (MUR), Research and Innovation” resources—Green/Innovation Action
Do the authors have ties to companies?no — the authors say so
Did a manufacturer help with the study?NO
Type of studylaboratory study (on cells)

“Not stated” does not mean nobody paid — the database does not always record it.

The review describes results from cell and inflammation models suggesting that olive leaf polyphenols may reduce DNA damage and processes linked to cancer development.

Aim of the study: The traditional Mediterranean diet (MD) is associated with a long life and a lower prevalence of cardiovascular disease and cancer. Its main components include a high intake of fruit, vegetables, red wine, extra virgin olive oil (EVOO), and fish, and a low intake of dairy products and red meat.

Results: The pathways and signaling cascades affected include the NF-κB inflammatory response and the oxidative stress response, but the effects of these bioactive components may also result from their action as phytoestrogens. Because olive polyphenols have a structure similar to that of estrogens, researchers have suggested that they may interact with estrogen receptors, thereby reducing the prevalence and progression of hormone-related cancers. Evidence for the protective effects of olive polyphenols against cancer in humans remains anecdotal, and clinical trials are needed to support these claims. This review aims to bring together the current literature on the bioavailability and mechanisms involved in the potential anticancer effects of olive leaf polyphenols.

Evidence to Support the Anti-Cancer Effect of Olive Leaf Extract and Future Directions. · Nutrients 2016
Money for the studynot stated
Do the authors have ties to companies?no — the authors say so
Did a manufacturer help with the study?NO
Type of studydiscussion of other studies

“Not stated” does not mean nobody paid — the database does not always record it.

Perspectives and opinion materials

The content below presents the authors’ opinions, interpretations and hypotheses. It is not treated as equal to scientific studies and systematic reviews.

Orthomolecular Medicine News Service Opinion material
„Olive Leaf Extract — Olives are one of the cornerstones of the Mediterranean diet and have helped people stay healthy for thousands of years. One of the main functions of olive leaf extract is to prevent viral infections. It has also been shown to improve cardiovascular health, lower blood pressure, and protect organs such as the pancreas, liver, and kidneys. Olive leaf extract has anti-inflammatory properties and has been shown to repair tissue damage related to kidney disease, upper respiratory illnesses, fatty liver disease, and heart disease. (A possible dosage is 500–1,000 mg/day, split into doses of 250 mg each.)”Olive Leaf Extract - Olives are one of the cornerstones of the Mediterranean Diet and have been helping people to be healthier for thousands of years. One of the primary functions of olive leaf extract is to prevent viral infections. However, it has also been shown to improve cardiovascular health, lower blood pressure and protect organs such as the pancreas, liver and the kidneys. Olive Leaf Extract has anti-inflammatory properties and has been proven to repair tissue damage related to kidney disease, upper respiratory illnesses, fatty liver disease and heart disease. (Possible dosage is 500-1,000 mg/day in split doses of 250 mg each dose).
A Health Crisis Exposed by the COVID Pandemic
Orthomolecular Medicine News Service Opinion material
„(2005) A thromboxane effect of a hydroxytyrosol-rich olive oil wastewater extract in patients with uncomplicated type I diabetes. European Journal of Clinical Nutrition 59:727–730. PMID: 15798774 88. Dell'Agli M, Maschi O, Galli G et al. (2008) Inhibition of platelet aggregation by olive oil phenols via cAMP-phosphodiesterase. The British Journal of Nutrition 99:945–951. PMID: 17927845 89. Moreno-Luna R, Munoz-Hernandez R, Miranda M et al. (2012) Olive oil polyphenols decrease blood pressure and improve endothelial function in young women with mild hypertension. American Journal of Hypertension 25:1299–1304. PMID: 22914255 90.”(2005) A thromboxane effect of a hydroxytyrosol-rich olive oil wastewater extract in patients with uncomplicated type I diabetes. European Journal of Clinical Nutrition 59:727-730. PMID: 15798774 88. Dell'Agli M, Maschi O, Galli G et al. (2008) Inhibition of platelet aggregation by olive oil phenols via cAMP-phosphodiesterase. The British Journal of Nutrition 99:945-951. PMID: 17927845 89. Moreno-Luna R, Munoz-Hernandez R, Miranda M et al. (2012) Olive oil polyphenols decrease blood pressure and improve endothelial function in young women with mild hypertension. American Journal of Hypertension 25:1299-1304. PMID: 22914255 90.
The Restoration of Vitamin C Synthesis in Humans
Orthomolecular Medicine News Service Opinion material
„years Australia Dietary intake Highest intake of fish oil reduced relative risk for early AMD by 59% Archives of Ophthalmology Aug 2001 Dietary PREVENTION – 34955–80 years of age Boston, MA Dietary intake Greater fish consumption reduced risk for AMD Am J Clinical Nutrition Feb 2001 Dietary PREVENTION – 7248950+ years of age Boston, MA Dietary intake Highest DHA intake reduced relative risk for AMD by 30%; more than 4 servings of fish/week reduced AMD risk by 35% Archives of Ophthalmology March 2000 Dietary PREVENTION – 365449+ years of age Australia Dietary intake Fish consumption associated with reduced risk for advanced AMD 1 One line of letters on the visual acuity chart = 5 letters 2 Olive oil was shown to halve the risk of developing advanced AMD in another study (Archives of Ophthalmology 127: 674, May 2009), so it was not a wise choice of placebo.”years Australia Dietary intake Highest intake of fish oil reduced relative risk for early AMD 59% Archives Ophthalmology Aug 2001 Dietary PREVENTION – 34955-80 yrs of age Boston, MA Dietary intake Greater fish consumption reduced risk for AMD Am J Clinical Nutrition Feb 2001 Dietary PREVENTION – 7248950+ yrs of age Boston, MA Dietary intake Highest DHA intake reduced relative risk for AMD 30%; more than 4 servings of fish/week reduced AMD risk 35% Archives Ophthalmology March 2000 Dietary PREVENTION – 365449+ years of age Australia Dietary intake Fish consumption associated with reduced risk for advanced AMD 1 One line of letters on the visual acuity chart = 5 letters 2 Olive oil shown to halve risk to develop advanced AMD in another study (Archives Ophthalmology 127: 674, May 2009), so not wise choice of placebo.
Something’s Fishy About Macular Degeneration Fish Oil Studies

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