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Heart and cholesterol: Does a plate of vegetables work better than statins?

Sources: 11 · Article: 18 497 characters

Ewa Dąbrowska claims that a fruit-and-vegetable fast reverses atherosclerotic changes, but does not explicitly say that it treats coronary artery disease.

  • Ischaemic heart disease is caused by atherosclerosis, which can narrow blood vessels and limit blood flow to the heart.
  • Ewa Dąbrowska adds that fasting may improve the strength of the heart’s contractions; in monitored patients, cholesterol initially rose temporarily.

What the authors write

Ewa Dąbrowska

During fasting, when the body stops receiving calories, atherosclerotic changes are said to reverse.

„It is very interesting that, during fasting, when the supply of calories is interrupted and the body switches to internal nourishment, atherosclerotic changes reverse. First, visceral fat is reduced and blood sugar and blood pressure return to normal; even blood clots attached to atherosclerotic plaques dissolve.”To jest bardzo ciekawe, że w przypadku postu, gdy jest przerwany dowóz kalorii i organizm przestawia się na odżywianie wewnętrzne, zmiany miażdżycowe się cofają. W pierwszym rzędzie następuje redukcja tłuszczu trzewnego i normalizacja poziomu cukru, ciśnienia, nawet zakrzepy przylegające do blaszek miażdżycowych ulegają rozpuszczeniu.
Ewa Dąbrowska

Fasting is said to reduce visceral fat, normalize blood sugar and blood pressure, and dissolve blood clots near atherosclerotic plaques.

„First, visceral fat is reduced and blood sugar and blood pressure return to normal; even blood clots attached to atherosclerotic plaques dissolve. All protein deposits are converted into glucose. Fasting also increases the strength of the heart’s contractions because it improves the function of mitochondria1, the cell organelles where energy is produced.”W pierwszym rzędzie następuje redukcja tłuszczu trzewnego i normalizacja poziomu cukru, ciśnienia, nawet zakrzepy przylegające do blaszek miażdżycowych ulegają rozpuszczeniu. Wszelkie złogi białkowe zamieniane są na glukozę. Post zwiększa też siłę skurczu serca, gdyż poprawia funkcje mitochondriów1, organelli komórkowych, w których powstaje energia.
Ewa Dąbrowska

Fasting is said to increase the strength of the heart’s contractions and improve its function.

„Fasting also increases the strength of the heart’s contractions because it improves the function of mitochondria1, the cell organelles where energy is produced. Improved heart function triggers a diuretic effect and the swelling goes away. In a group of patients with atherosclerosis whose cholesterol we monitored during a fruit-and-vegetable diet, blood cholesterol temporarily increased, which”Post zwiększa też siłę skurczu serca, gdyż poprawia funkcje mitochondriów1, organelli komórkowych, w których powstaje energia. Zwiększenie wydolności serca uruchamia działanie moczopędne i następuje likwidacja obrzęków. W grupie chorych z miażdżycą, u których w trakcie diety warzywno-owocowej monitorowaliśmy cholesterol, nastąpił przejściowy wzrost cholesterolu we krwi, co
Ewa Dąbrowska

Blood cholesterol temporarily increased during a fruit-and-vegetable diet in monitored patients with atherosclerosis.

„Fasting also increases the strength of the heart’s contractions because it improves the function of mitochondria1, the cell organelles where energy is produced. Improved heart function triggers a diuretic effect and the swelling goes away. In a group of patients with atherosclerosis whose cholesterol we monitored during a fruit-and-vegetable diet, blood cholesterol temporarily increased, which”Post zwiększa też siłę skurczu serca, gdyż poprawia funkcje mitochondriów1, organelli komórkowych, w których powstaje energia. Zwiększenie wydolności serca uruchamia działanie moczopędne i następuje likwidacja obrzęków. W grupie chorych z miażdżycą, u których w trakcie diety warzywno-owocowej monitorowaliśmy cholesterol, nastąpił przejściowy wzrost cholesterolu we krwi, co
Ewa Dąbrowska

Ischaemic heart disease is caused by atherosclerosis, and restricted blood flow to the heart can lead to a heart attack.

„Reduced blood flow to the heart or brain can result in a heart attack or stroke. Ischaemic heart disease, which results from atherosclerosis, remains the leading cause of death worldwide. Atherosclerosis can develop as early as childhood. It can remain symptom-free for many years.”Zmniejszony przepływ krwi do serca lub mózgu może skutkować zawałem lub udarem. Choroba niedokrwienna serca, wynikająca z miażdżycy, pozostaje główną przyczyną zgonów na świecie. Miażdżyca może rozwijać się nawet już od dzieciństwa. Przez długie lata przebiega bezobjawowo.
Ewa Dąbrowska

Atherosclerosis involves the buildup of plaques and the narrowing of blood vessels.

„Atherosclerosis Atherosclerosis is a chronic inflammatory disease of the arteries that causes atherosclerotic plaques to build up and blood vessels to narrow. Reduced blood flow to the heart or brain can result in a heart attack or stroke. Ischaemic heart disease, which results from atherosclerosis, remains the leading cause of death worldwide.”Miażdżyca Miażdżyca to przewlekła choroba zapalna tętnic, prowadząca do odkładania się blaszek miażdżycowych i zwężenia naczyń krwionośnych. Zmniejszony przepływ krwi do serca lub mózgu może skutkować zawałem lub udarem. Choroba niedokrwienna serca, wynikająca z miażdżycy, pozostaje główną przyczyną zgonów na świecie.
Ewa Dąbrowska

Ewa Dąbrowska links atherosclerosis with insulin resistance and claims that fasting reduces excess body fat and reverses fatty liver disease.

„Fasting helps reduce excess body fat and reverses fatty liver disease. As a result, cells become more sensitive to insulin. This is important because insulin resistance underlies many metabolic diseases: type 2 diabetes, atherosclerosis, high blood pressure, lipid disorders, and gout.”Post wspomaga redukcję nadmiaru tkanki tłuszczowej i cofa stłuszczenie wątroby. W efekcie poprawia się wrażliwość komórek na insulinę, co jest kluczowe, ponieważ insulinooporność leży u podstaw wielu chorób metabolicznych: cukrzycy typu 2, miażdżycy, nadciśnienia, zaburzeń lipidowych czy dny moczanowej.
Ewa Dąbrowska

Ewa Dąbrowska again links atherosclerosis with insulin resistance and attributes the reduction of excess body fat and reversal of fatty liver disease to fasting.

„Metabolic diseases Fasting helps reduce excess body fat and reverses fatty liver disease. As a result, cells become more sensitive to insulin. This is important because insulin resistance underlies many metabolic diseases: type 2 diabetes, atherosclerosis, high blood pressure, lipid disorders, and gout.”Choroby metabolicznePost wspomaga redukcję nadmiaru tkanki tłuszczowej i cofa stłuszczenie wątroby. W efekcie poprawia się wrażliwość komórek na insulinę, co jest kluczowe, ponieważ insulinooporność leży u podstaw wielu chorób metabolicznych: cukrzycy typu 2, miażdżycy, nadciśnienia, zaburzeń lipidowych czy dny moczanowej.
Ewa Dąbrowska

Ewa Dąbrowska points out that lifestyle, especially a diet high in processed foods and a lack of physical activity, matters in the development of atherosclerosis.

„Lifestyle—especially a diet high in processed foods and a lack of physical activity—plays a key role in its development. The so-called Western diet contributes to diseases of civilization, including atherosclerosis. The 1994 INTERHEART study found that the risk of a heart attack could be reduced by as much as 80% by following three rules: eat vegetables and fruit, be physically active, Atherosclerosis begins with damage to the endothelium—the inner lining of blood vessels.”Styl życia – zwłaszcza dieta bogata w przetworzoną żywność i brak ruchu – odgrywa kluczową rolę w jej rozwoju. Tzw. dieta zachodnia sprzyja chorobom cywilizacyjnym, w tym miażdżycy. Badanie INTERHEART z 1994 roku wykazało, że ryzyko zawału serca można zmniejszyć aż o 80%, przestrzegając trzech zasad: jedz warzywa i owoce, bądź aktywny fizycznie, Miażdżyca zaczyna się od uszkodzenia śródbłonka – wewnętrznej wyściółki naczyń.
Ewa Dąbrowska

Ewa Dąbrowska says that the INTERHEART study found that following three rules could reduce the risk of a heart attack by as much as 80%.

„The 1994 INTERHEART study found that the risk of a heart attack could be reduced by as much as 80% by following three rules: eat vegetables and fruit, be physically active, Atherosclerosis begins with damage to the endothelium—the inner lining of blood vessels. One possible cause is vitamin C deficiency.”Badanie INTERHEART z 1994 roku wykazało, że ryzyko zawału serca można zmniejszyć aż o 80%, przestrzegając trzech zasad: jedz warzywa i owoce, bądź aktywny fizycznie, Miażdżyca zaczyna się od uszkodzenia śródbłonka – wewnętrznej wyściółki naczyń. Jedną z przyczyn może być niedobór witaminy C.

Research from PubMed · Europe PMC

We selected 8 studies with the best, positive results. This is a selection, not a full review of all research.

Total number of studies on this topic in PubMed: 34.

A review indicates that the Mediterranean diet reduces cardiovascular events more effectively than a low-fat diet, but does not show that a fruit-and-vegetable fast reverses atherosclerosis.

Aim of the study: Our understanding of the potential cardioprotective properties of nutrition is relatively recent, with most relevant studies completed in the last several decades. During that time, there has been an evolution in the focus of nutritional intervention.

Results: During that time, there has been an evolution in the focus of nutritional intervention. Early trials emphasized reduction of dietary fat with the goal of preventing heart disease by reducing serum cholesterol. Results from trials focused exclusively on dietary fat reduction were disappointing, prompting subsequent studies incorporating a whole diet approach with a nuanced recommendation for fat intake. The Mediterranean-style diet, with a focus on vegetables, fruit, fish, whole grains, and olive oil, has proven to reduce cardiovascular events to a degree greater than low-fat diets and equal to or greater than the benefit observed in statin trials.

Money for the studynot stated
Do the authors have ties to companies?not stated
Did a manufacturer help with the study?unknown
Type of studydiscussion of other studies

“Not stated” does not mean nobody paid — the database does not always record it.

The description indicates that a healthy diet rich in fiber, fruit, and vegetables may limit the development and progression of atherosclerosis, but does not discuss fasting or reversal of the disease.

Aim of the study: The favorable effect of a healthy diet on the initial development and the further progression of atherosclerosis has been demonstrated. The effect is significant even in patients with adequate pharmacological treatment.

Results: Therefore fatty fish more than once a week, nuts, fruits and vegetables (>400 g/day) have a prognostically favorable effect, whereas the supplemental use of antioxidative vitamins is of no proven benefit. These recommendations result from the experience gained over generations in millions of people in different countries (Mediterranean and Asian) with a low rate of coronary events and a high life expectancy. These dietary habits are associated with a low rate of neoplasm and of osteoporosis. The recommendation for this type of diet is a class-I recommendation.

[Nutrition]. · Z Kardiol 2005
Money for the studynot stated
Do the authors have ties to companies?not stated
Did a manufacturer help with the study?unknown
Type of studyother

“Not stated” does not mean nobody paid — the database does not always record it.

The review lists a healthy diet with fruit and vegetables as a lifestyle factor associated with lower cardiac risk, but does not confirm that fasting reverses atherosclerosis.

Aim of the study: In this article, we compare two strategies for atherosclerosis treatment: drugs and healthy lifestyle. Statins are the principal drugs used for the treatment of atherosclerosis.

Results: Nevertheless, there are difficulties in implementing these measures both at the individual and population levels. Changes in behavior require multidisciplinary care, including medical, nutritional, and psychological counseling. Participation of the entire society is required for such implementation, i.e., universities, schools, media, government, and medical societies. Although these efforts represent a major challenge, such a task must be faced in order to halt the atherosclerosis epidemic that threatens the world.

Money for the studyuniversity or foundation
Do the authors have ties to companies?not stated
Did a manufacturer help with the study?unknown
Type of studydiscussion of other studies

“Not stated” does not mean nobody paid — the database does not always record it.

In the study, greater adherence to the PURE diet, which includes fruit and vegetables, was associated with a lower risk of premature coronary artery disease, but fasting and reversal of the disease were not studied.

Aim of the study: Although dietary approaches to stop hypertension (DASH) and Mediterranean diets have been shown to reduce cardiovascular risk, their regional applicability may be limited. The PURE healthy diet, with an emphasis on consumption of certain food groups rather than limiting others, may provide a more culturally appropriate approach.

Results: Greater adherence to the PURE healthy diet was associated with a significant reduction in PCAD risk. Participants in the highest quartile had a 66% lower likelihood of having PCAD compared to those in the lowest quartile (OR = 0.34; 95% CI: 0.26-0.46; p < 0.001). Nuts (OR = 0.56, 95% CI: 0.43-0.73, P for trend < 0.001) and legumes (OR = 0.72, 95% CI: 0.55-0.95, P for trend < 0.004) were major contributors to this protection, as their removal weakened the association. The PURE healthy diet shows strong potential in reducing the risk of PCAD, with this inverse association persisting even after excluding one of the six food groups. However, longitudinal studies are essential to confirm these findings.

Money for the studygovernment, public institutions · Research and Technology Department of the Iran Ministry of Health and Medical Education, Iranian Network of Cardiovascular Research
Do the authors have ties to companies?no — the authors say so
Did a manufacturer help with the study?NO
Type of studyobservation of people
Participants3 183

“Not stated” does not mean nobody paid — the database does not always record it.

The study found that eating fruit and vegetables more often was associated with a lower risk of premature coronary artery disease, but did not assess fasting or the regression of atherosclerosis.

Aim of the study: Few investigations have examined the association of fruits and vegetables with premature coronary artery disease (PCAD) in the Eastern Mediterranean region. This study aimed to evaluate the association between fruits and vegetables intake and PCAD, as well as its severity.

Results: In both genders, greater intake of fruits, vegetables, and total fruits and vegetables was considerably and negatively associated with the risk of PCAD. Furthermore, the severity of PCAD was inversely correlated with fruits and vegetables intake (p < 0.001). We found an inverse relationship between fruits and vegetables consumption with odds of PCAD in Iranian ethnicities. Our findings highlight dietary habits' role in reducing PCAD risk and severity, guiding prevention and clinical care.

Money for the studygovernment, public institutions · Research and Technology Department, Iran Ministry of Health and Medical Education, Iranian Network of Cardiovascular Research
Do the authors have ties to companies?no — the authors say so
Did a manufacturer help with the study?NO
Type of studyobservation of people
Participants3 249

“Not stated” does not mean nobody paid — the database does not always record it.

Greater fruit and vegetable intake in early adulthood was associated with a lower prevalence of coronary artery calcification 20 years later, but does not prove that fasting reverses these changes.

Aim of the study: The relationship between intake of fruits and vegetables (F/V) during young adulthood and coronary atherosclerosis later in life is unclear.

Results: We studied participants of the Coronary Artery Risk Development in Young Adults (CARDIA) study, a cohort of young, healthy black and white individuals at baseline (1985-1986). Intake of F/V at baseline was assessed using a semiquantitative interview administered diet history, and coronary artery calcium was measured at year 20 (2005-2006) using computed tomography. We used logistic regression to adjust for relevant variables and estimate the adjusted odds ratios and 95% confidence intervals across energy-adjusted, sex-specific tertiles of total servings of F/V per day. Among our sample (n=2506), the mean (SD) age at baseline was 25.3 (3.5) years, and 62.7% were female. After adjustment for demographics and lifestyle variables, higher intake of F/V was associated with a lower prevalence of coronary artery calcium: odds ratio (95% confidence interval) =1.00 (reference), 0.78 (0.59-1.02), and 0.74 (0.56-0.99), from the lowest to the highest tertile of F/V, P value for trend <0.001.

Money for the studygovernment, public institutions · NHLBI NIH HHS, NIDDK NIH HHS, Intramural NIH HHS
Do the authors have ties to companies?not stated
Did a manufacturer help with the study?unknown
Type of studyobservation of people
Participants2 506

“Not stated” does not mean nobody paid — the database does not always record it.

More frequent fruit and vegetable consumption was associated with a lower likelihood of peripheral artery disease, but the study did not assess fasting or coronary artery disease.

Aim of the study: Although fruit and vegetable (F&V) consumption is associated with lower risk of coronary heart disease and stroke, its association with peripheral artery disease (PAD) is less certain. We, thus, sought to characterize F&V intake and investigate the association between F&V consumption and presence of PAD in a large community sample.

Results: Self-referred participants at >20 000 US sites who completed medical and lifestyle questionnaires were evaluated by screening ankle brachial indices for PAD (ankle brachial index ≤0.9). Among 3 696 778 individuals, mean age was 64.1±10.2 years and 64.1% were female. Daily consumption of ≥3 servings of F&V was reported by 29.2%. Increasing age, female sex, white race, never smoking, being currently married, physical activity, increasing income, and frequent consumption of fish, nuts, and red meat were positively associated with daily consumption of F&V. After multivariable adjustment, there was a stepwise inverse association between F&V intake and PAD. Participants reporting daily intake of ≥3 servings of F&V had 18% lower odds of PAD than those reporting less than monthly consumption. In unadjusted and multivariable-adjusted models, the inverse association with F&V became stronger as ankle brachial index decreased.

Money for the studygovernment, public institutions · NHLBI NIH HHS, NCATS NIH HHS
Do the authors have ties to companies?not stated
Did a manufacturer help with the study?unknown
Type of studyobservation of people
Participants3 696 778

“Not stated” does not mean nobody paid — the database does not always record it.

A meta-analysis found that a plant-based diet, especially a healthy one, is associated with a lower risk of coronary heart disease, but does not prove that it reverses existing atherosclerosis or coronary artery disease.

Aim of the study: Background/Objectives: This study aimed to examine the association between a plant-based diet (PBD) and the incidence of total cardiovascular disease (CVD), coronary heart disease (CHD), and stroke in a meta-analysis of prospective cohort studies.

Results: We found no significant association with stroke risk. Conclusions: This meta-analysis indicated that a PBD was inversely associated with the risk of CVD and CHD. A hPBD showed an inverse association, whereas a uPBD showed a positive association between cardiovascular health. Further well-designed interventions are needed to clarify these associations.

Money for the studynot stated
Do the authors have ties to companies?no — the authors say so
Did a manufacturer help with the study?NO
Type of studycombined analysis of many studies (meta-analysis)

“Not stated” does not mean nobody paid — the database does not always record it.

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