DiseasesInsulin resistance — a silent epidemic we learn about too late?
Sources: 10 · Article: 9 516 characters
The Rodzeń brothers warn that insulin resistance can develop over many years, even when glucose levels are normal and insulin is working very hard.
- According to them, early diagnosis and lifestyle changes can stop the disease, and insulin resistance is reversible.
- Jan Jaśkowski calls insulin resistance and diabetes the epidemic of our time, one that can be prevented.
- Physical activity can lower blood glucose and triglyceride levels and have a positive effect on metabolism.
What the authors write
Bracia Rodzeń
Insulin resistance can develop silently for years, even when glucose is still within the normal range and insulin is already working very hard.
„Insulin resistance can develop silently for years. Glucose may still be “normal,” while insulin is already working at full capacity.
This mechanism can affect body weight, energy, hormonal balance, and metabolic health.
Don’t look only at glucose.”Insulinooporność przez lata może rozwijać się po cichu. Glukoza bywa jeszcze „w normie”, a insulina już pracuje na wysokich obrotach.
To mechanizm, który może wpływać na masę ciała, energię, gospodarkę hormonalną i zdrowie metaboliczne.
Nie patrz tylko na glukozę.
Bracia Rodzeń
Early diagnosis and lifestyle changes can stop the disease; insulin resistance is reversible.
„Insulin resistance is reversible. Early diagnosis and lifestyle changes can stop the disease.”Insulinooporność jest odwracalna. Wczesna diagnoza i zmiana stylu życia mogą zatrzymać chorobę.
Jan Jaśkowski
Insulin resistance and diabetes have been called the epidemic of our time, one that can be prevented.
„Insulin resistance and diabetes are a real epidemic of our time, with very serious consequences for health. Fortunately, they can be prevented. It turns out that doing squats lowers blood glucose by 30%! Remember that glucose is stored as glycogen in the liver and muscles.”Insulinooporność i cukrzyca to prawdziwa epidemia naszych czasów z bardzo poważnymi skutkami dla zdrowia. Na szczęście można im zapobiegać. Okazuje się, że wykonywanie przysiadów zmniejsza stężenie glukozy we krwi o 30%! Pamiętajmy, że glukoza jest magazynowana w postaci glikogenu w wątrobie i mięśniach.
Jan Jaśkowski
Physical activity can lower blood glucose and triglyceride levels, which, according to Jan Jaśkowski, has a positive effect on metabolism.
„It turns out that doing squats lowers blood glucose by 30%! Remember that glucose is stored as glycogen in the liver and muscles. The greater your muscle mass, the more glycogen you can store. Physical activity also lowers blood triglyceride levels, which has a positive effect on metabolism.”Okazuje się, że wykonywanie przysiadów zmniejsza stężenie glukozy we krwi o 30%! Pamiętajmy, że glukoza jest magazynowana w postaci glikogenu w wątrobie i mięśniach. Im większa masa mięśniowa, tym więcej glikogenu możemy zmagazynować. Aktywność fizyczna zmniejsza także stężenie trójglicerydów we krwi, co pozytywnie wpływa na metabolizm.
Bracia Rodzeń
The Rodzeń brothers link higher carbohydrate intake to weight gain and the risk of insulin resistance and other metabolic diseases.
„The more carbohydrates you eat, the faster and more weight you will gain, and the more likely you are to develop insulin resistance and other metabolic diseases.
obesity/insulin resistance,
metabolic diseases (type 2 diabetes, fatty liver, high blood pressure, PCOS, numerous cancers).”Im więcej węglowodanów w Twoich pokarmach, tym szybciej i bardziej przytyjesz, zachorujesz na insulinooporność i inne choroby metaboliczne.
otyłość/insulinooporność,
choroby metaboliczne (cukrzyca typu 2, stłuszczenie wątroby, nadciśnienie tętnicze, PCOS, liczne nowotwory).
M. S. Sater i H. A. Giha
Type 2 diabetes is a chronic metabolic disease associated with insulin resistance; without management, it can lead to long-term damage to important organs.
„It is characterized by insulin resistance (IR) and relative insulin deficiency, leading to chronic hyperglycemia, which, if unmanaged, causes severe, long-term damage to major organs [1]. T2D is a highly heterogeneous metabolic disorder characterized by diverse genetic and environmental etiologies and complex pathophysiology [2].”It is characterized by insulin resistance (IR) and relative insulin deficiency, leading to chronic hyperglycemia, which, if unmanaged, causes severe, long-term damage to major organs [1]. T2D is a highly heterogeneous metabolic disorder characterized by diverse genetic and environmental etiologies and complex pathophysiology [2].
M. Williamson i N. Moustaid-Moussa i L. Gollahon
Insulin resistance was listed among metabolic disorders that often occur together and share risk factors, such as a poor diet.
„This list encompasses a wide range of disorders that have been linked to each other because they often manifest in combination and share risk factors like poor diet. These diseases also share many symptoms like glucose and hormone imbalance, excess calcium excretion, and oxidative stress.”This list encompasses a wide range of disorders that have been linked to each other because they often manifest in combination and share risk factors like poor diet. These diseases also share many symptoms like glucose and hormone imbalance, excess calcium excretion, and oxidative stress.
Research from PubMed · Europe PMC
We selected 2 studies with the best, positive results. This is a selection, not a full review of all research.
Total number of studies on this topic in PubMed: 73 980.
The review indicates that insulin resistance and elevated insulin can occur even when blood glucose is normal, and that early detection may help prevent complications.
Aim of the study: Type 2 diabetes mellitus (T2DM) is increasing in prevalence worldwide, and those non-diagnosed or misdiagnosed comprise a significant group compared to those diagnosed.
Results: Insulin resistance and hyperhormonemia (insulin, amylin, glucagon) are non-disputable hallmarks of T2DM, which already takes place among these normoglycemic, otherwise health subjects, characterizing a state of subclinical diabetes. Insulin resistance and hyperinsulinemia can be computed from fasting plasma insulin as an independent variable in normoglycemia. An overview of the current diagnostic criteria, disease onset, complications, comorbidities and perspectives on lifestyle interventions are presented. A proposal for early detection of subclinical diabetes from routine evaluation of fasting plasma insulin, which is affordable and robust and thus applicable for the general population, is further suggested.
Money for the studynot stated
Do the authors have ties to companies?not stated
Did a manufacturer help with the study?unknown
Type of studydiscussion of other studies
“Not stated” does not mean nobody paid — the database does not always record it.
In a study of people with blood glucose disorders, the TyG index detected insulin resistance with 84% sensitivity, which may help identify it.
Aim of the study: Because the insulin test is expensive and is not available in most laboratories in the cities of undeveloped countries, we tested whether the product of fasting triglycerides and glucose levels (TyG) is a surrogate for estimating insulin resistance compared with the homeostasis model assessment of insulin resistance (HOMA-IR) index.
Results: A total of 748 apparently healthy subjects aged 41.4 +/- 11.2 years were enrolled. Insulin resistance was identified in 241 (32.2%) subjects (HOMA-IR index 4.4 +/- 1.6). New diagnoses of IFG, IGT, and IFG + IGT were established in 145 (19.4%), 54 (7.2%), and 75 (10.0%) individuals. respectively. The best TyG index for diagnosis of insulin resistance was Ln 4.65, which showed the highest sensitivity (84.0%) and specificity (45.0%) values. The positive and negative predictive values were 81.1% and 84.8%, and the probability of disease, given a positive test, was 60.5%. The TyG index could be useful as surrogate to identify insulin resistance in apparently healthy subjects.
Money for the studynot stated
Do the authors have ties to companies?not stated
Did a manufacturer help with the study?unknown
Type of studyobservation of people
Participants748
“Not stated” does not mean nobody paid — the database does not always record it.
Perspectives and opinion materials
The content below presents the authors’ opinions, interpretations and hypotheses. It is not treated as equal to scientific studies and systematic reviews.
Orthomolecular Medicine News Service Opinion material
„2.3 Diagnosis of Vitamin D Resistance Vitamin D resistance is a diagnosis of exclusion and involves a combination of clinical assessment, laboratory tests (including serum levels of 25(OH)D and PTH) and monitoring the response to vitamin D supplementation. Elevated PTH levels in conjunction with sufficient vitamin D status are particularly indicative of resistance (1).”2.3 Diagnosis of Vitamin D Resistance Vitamin D resistance is a diagnosis of exclusion and involves a combination of clinical assessment, laboratory tests (including serum levels of 25(OH)D and PTH) and monitoring the response to vitamin D supplementation. Elevated PTH levels in conjunction with sufficient vitamin D status are particularly indicative of resistance (1).
Orthomolecular Medicine News Service Opinion material
„HOMA-IR (HOMA-IR; homeostasis model assessment as an index of insulin resistance) is an effective method to calculate and evaluate insulin resistance using conventional reference lab biomarkers: insulin levels, fasting glucose levels, and A1C [60,61]. If you have these 3, you can then calculate the HOMA-IR. This enables accurate documentation and validates spending the modest expense to do the proper tests. As much as 70% of adults over the age of 30 do not have normal postprandial glucose (PPG). It's that bad! They say it's only 30% or 40%, but that's likely based on poor statistics.”HOMA-IR (HOMA-IR; homeostasis model assessment as an index of insulin resistance) is an effective method to calculate and evaluate insulin resistance using conventional reference lab biomarkers: insulin levels, fasting glucose levels, and A1C [60,61]. If you have these 3, you can then calculate the HOMA-IR. This enables accurate documentation and validates spending the modest expense to do the proper tests. As much as 70% of adults over the age of 30 do not have normal postprandial glucose (PPG). It's that bad! They say it's only 30% or 40%, but that's likely based on poor statistics.
Orthomolecular Medicine News Service Opinion material
„It looks like the benfotiamine had manipulated my insulin resistance. Why it seems to work My search of the literature indicates to me that benfotiamine has an effect on insulin resistance that thiamine by itself does not. Using benfotiamine to lower insulin resistance allows easier access for body sugars to reach the tissues. I think that easier access by the tissues allows stimulation of leptin (which controls satiety). This allows the side effect of benfotiamine of being a good appetite suppressant which, over a period of time, causes the loss of weight by ignoring some of your calories because you're not hungry.”It looks like the benfotiamine had manipulated my insulin resistance. Why it seems to work My search of the literature indicates to me that benfotiamine has an effect on insulin resistance that thiamine by itself does not. Using benfotiamine to lower insulin resistance allows easier access for body sugars to reach the tissues. I think that easier access by the tissues allows stimulation of leptin (which controls satiety). This allows the side effect of benfotiamine of being a good appetite suppressant which, over a period of time, causes the loss of weight by ignoring some of your calories because you're not hungry.
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