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Diet and nutrition

Gluten and modern wheat — why do so many people feel unwell after eating it?

Sources: 10 · Article: 11 263 characters

Henryk Różański points out that gluten may slow digestion and interfere with the action of bile and digestive enzymes.

  • Jerzy Zięba claims that gluten may damage the intestinal barrier and that glyphosate may make this problem worse.
  • Hubert Czerniak says that when the gut flora is damaged, gluten may not be broken down properly and may form compounds that, he claims, can cause mental dullness.
  • Henryk Różański recommends limiting gluten for people with, among other conditions, coeliac disease, inflammatory bowel conditions, constipation and bloating.

What the authors write

Henryk Różański

Gluten may slow the movement of food through the digestive tract and make digestion more difficult by interfering with the action of bile and enzymes.

„Gluten slows the passage of food through the digestive tract and can sometimes make food harder to digest by interfering with the penetration of food by bile and digestive enzymes. A higher proportion of fibre in flour-based dishes (for example, bran) offsets gluten’s adverse effects. It has been estimated that 36,000 people in Switzerland do not tolerate gluten.”Gluten spowalnia pasaż treści pokarmowej, niekiedy utrudnia trawienie pokarmu, przez zakłócanie penetracji masy pokarmowej przez żółć i enzymy trawienne. Większy udział włókna w potrawach mącznych (np. otręby) niweluje niekorzystne cechy glutenu. Oszacowano, że w Szwajcarii 36 000 osób nie toleruje glutenu.
Henryk Różański

Henryk Różański recommends low-gluten or gluten-free dishes for people with coeliac disease, inflammatory bowel conditions, irritable bowel syndrome, chronic constipation and bloating.

„People suffering from inflammation of the intestinal lining, irritable bowel syndrome, diverticulitis, coeliac disease, chronic constipation and bloating, and obesity should eat low-gluten and gluten-free dishes. Gluten slows the passage of food through the digestive tract and can sometimes make food harder to digest by interfering with the penetration of food by bile and digestive enzymes.”Niskoglutenowe i bezglutenowe potrawy powinny konsumować osoby cierpiące na stany zapalane błony śluzowej jelit, na zespół jelita drażliwego, zapalenie uchyłków jelita, celiakię i przewlekłe zaparcia i wzdęcia oraz otyłość. Gluten spowalnia pasaż treści pokarmowej, niekiedy utrudnia trawienie pokarmu, przez zakłócanie penetracji masy pokarmowej przez żółć i enzymy trawienne.
Jerzy Zięba

Jerzy Zięba claims that gluten may damage the tight junctions in the intestine and lead to what is known as leaky gut.

„But when tight junctions are destroyed, for example by gluten, glyphosate or other substances released by parasitic moulds (Candida albicans can also cause this), this is when we have leaky gut.”Kiedy jednak połączenie ścisłe zostają zniszczone, np. przez gluten, glifosat czy innego rodzaju substancje wydzielane przez pasożytnicze pleśnie. (np. Candida Albicans również może to zjawisko wywołać) wtedy właśnie mamy do czynienia z cieknącym jelitem.
Jerzy Zięba

Jerzy Zięba claims that glyphosate combined with gluten can make the intestine become a “sieve”.

„If glyphosate, the main active ingredient in the ubiquitous Roundup, is involved in this process, the intestine literally becomes a sieve. Gluten is literally everywhere in Poland. Gluten from wheat is particularly dangerous. A few days ago, in a supermarket, I noticed a very expensive “chimney-smoked” pork tenderloin.”Jeśli w tym procesie weźmie udział główny czynnik wszechobecnego Roundup-u jakim jest glifosat, wtedy z jelita robi się dosłownie sito. W Polsce gluten jest dosłownie wszędzie. Szczególnie groźny jest gluten z pszenicy. Kilka dni temu w jednym z supermarketów zauważyłem bardzo drogą polędwicę „z komina”.
Jerzy Zięba

Jerzy Zięba lists gluten and glyphosate as factors that may cause the intestinal barrier to become leaky.

„One of the many factors that can cause the intestinal barrier to become leaky is the gluten mentioned earlier, as well as ubiquitous glyphosate, the active ingredient in the herbicide Roundup, made by the giant Monsanto corporation. Anyone interested in these subjects knows that Roundup is the most widely used weedkiller.”Jednym z wielu czynników, które mogą doprowadzić do rozszczelnienia jelita jest wspomniany wcześniej gluten oraz wszechobecny glifosat, który jest składnikiem czynnym herbicydu pod nazwą Roundup produkowanego przez gigantyczny koncern Monsanto. Każda osoba interesująca się tymi tematami wie, że Roundup jest najczęściej stosowanym środkiem chwastobójczym.
Hubert Czerniak

Hubert Czerniak links a lack of an enzyme in damaged gut flora with the incomplete digestion of gluten and the formation of gluteomorphin, which he describes as a compound that causes mental dullness.

„Without this enzyme, casein and gluten are not broken down into small pieces because damaged gut bacteria do not have the enzyme. This is often the case in children with ASD. This is how caseomorphin and gluteomorphin are formed. They enter the bloodstream, where they stimulate opioid receptors and cause mental dullness.”Brak tego enzymu powoduje, że kazeina i gluten nie są trawione na małe kawałki, ponieważ uszkodzona flora bakteryjna nie posiada tego enzymu, co często dotyczy dzieci z grupy ASD. I tak powstają kazeomorfina i gluteomorfina, które wnikają do krwiobiegu, a to substancje pobudzające receptory opioidowe i powodujące otępienie.

Research from PubMed · Europe PMC

We selected 3 studies with the best, positive results. This is a selection, not a full review of all research.

Total number of studies on this topic in PubMed: 917.

A review estimated that about 10% of those surveyed reported gluten or wheat sensitivity, most commonly with bloating and abdominal complaints.

Aim of the study: Non-coeliac gluten/wheat sensitivity (NCGWS) is characterised by gastrointestinal and extraintestinal symptoms related to gluten or wheat ingestion in individuals without coeliac disease or wheat allergy. A systematic review and meta-analysis was conducted to estimate the global burden and clinical characteristics of self-reported NCGWS.

Results: Twenty-five studies comprising 49 476 participants from 16 countries were included in the analysis. The pooled prevalence of self-reported NCGWS was 10.3% (95% CI 7.0% to 14.0%), with marked variations between countries. Among individuals reporting NCGWS, 40% (95% CI 25.2% to 55.0%) adhered to a gluten-free diet. The most common symptoms were bloating (71.0%; 95% CI 62.8% to 79.1%), abdominal discomfort (46.0%; 95% CI 39.0% to 52.7%), abdominal pain (36.0%; 95% CI 28.6% to 43.2%) and fatigue (32.1%; 95% CI 25.3% to 39.0%). Self-reported NCGWS was significantly more common in females than in males (OR 2.29; 95% CI 1.80 to 2.90; p<0.001). Individuals who self-reported NCGWS were significantly more likely to report anxiety (OR 2.95; 95% CI 1.56 to 5.57; p<0.001), depression (OR 2.42; 95% CI 1.80 to 3.24; p<0.001) and irritable bowel syndrome (OR 4.78; 95% CI 3.48 to 6.57; p<0.001) than controls.

Money for the studynot stated
Do the authors have ties to companies?not stated
Did a manufacturer help with the study?unknown
Type of studycombined analysis of many studies (meta-analysis)
Participants49 476

“Not stated” does not mean nobody paid — the database does not always record it.

A review indicates that symptoms attributed to gluten may also be caused by fermentable carbohydrates and expectations related to food.

Aim of the study: Non-coeliac gluten sensitivity (NCGS) refers to individuals who report intestinal and extraintestinal symptoms related to the ingestion of gluten-based or wheat-based foods, in the absence of coeliac disease or wheat allergy. Gluten is found in multiple cereals, including wheat, rye, and barley, although the precise trigger of symptoms in NCGS remains unclear.

Results: Definitive diagnosis of NCGS remains elusive due to the absence of biomarkers, significant overlap with disorders of gut-brain interaction, and methodological challenges in dietary evaluation. Until causative agents are identified and diagnostic tests developed, NCGS remains a diagnosis of exclusion, requiring careful systematic evaluation. Management approaches should balance dietary modification with recognition of psychological factors while ensuring nutritional adequacy. This Review critically examines current evidence regarding NCGS as a distinct entity, explores potential mechanisms, and provides practical guidance for assessment and management, while acknowledging major uncertainties in the field.

Money for the studygovernment, public institutions · National Health and Medical Research Council
Do the authors have ties to companies?not stated
Did a manufacturer help with the study?unknown
Type of studydiscussion of other studies

“Not stated” does not mean nobody paid — the database does not always record it.

A review reports that fructans and amylase-trypsin inhibitors may also make wheat problematic, and that a gluten-free diet helps some people with wheat-related IBS symptoms.

Aim of the study: To describe recent advances on nonceliac gluten sensitivity (NCGS), a recently described disorder characterized by variable symptoms and frequent irritable bowel syndrome (IBS)-like manifestations.

Results: The recent description of disease-triggering wheat components other than gluten, such as fructans and amylase-trypsin inhibitors (ATIs), definitely suggests that nonceliac wheat sensitivity (NCWS) is a better 'umbrella' terminology than NCGS. Self-reported NCWS is very common worldwide, particularly in patients seen at the gastroenterology clinic, but many of these diagnoses are not confirmed by standard clinical criteria. A biomarker of NCWS is still lacking, however, subtle histological features at the small intestinal biopsy may facilitate diagnosis. Treatment of NCWS is based on the gluten-free diet (GFD). The GFD has proven to be an effective treatment of a significant proportion of NCWS-related IBS patients. Dietary therapies for IBS, including the GFD, should be offered by dietitians who first assess dietary triggers and then tailor the intervention according to patient choice.

Nonceliac gluten sensitivity. · Curr Opin Clin Nutr Metab Care 2023
Money for the studynot stated
Do the authors have ties to companies?yes — the authors reported it
Did a manufacturer help with the study?YES
Type of studydiscussion of other studies

“Not stated” does not mean nobody paid — the database does not always record it.

Perspectives and opinion materials

The content below presents the authors’ opinions, interpretations and hypotheses. It is not treated as equal to scientific studies and systematic reviews.

Orthomolecular Medicine News Service Opinion material
„Perlmutter always checks for gluten sensitivity in patients he receives with MS diagnosis. He advises that all MS patients should consider trying a gluten-free diet for at least 2 weeks. You may think that since you never had a problem with gluten in products from wheat, such as bread, that you never will. However, physicians focused on this issue have observed that with aging, everyone is more likely to develop a gluten allergy. Dr. Perlmutter suggests eliminating gluten (no more bread or pasta). For some people, to stop eating gluten can be terribly difficult. For most people, bread is a part of daily life.”Perlmutter always checks for gluten sensitivity in patients he receives with MS diagnosis. He advises that all MS patients should consider trying a gluten-free diet for at least 2 weeks. You may think that since you never had a problem with gluten in products from wheat, such as bread, that you never will. However, physicians focused on this issue have observed that with aging, everyone is more likely to develop a gluten allergy. Dr. Perlmutter suggests eliminating gluten (no more bread or pasta). For some people, to stop eating gluten can be terribly difficult. For most people, bread is a part of daily life.
Orthomolecular Medicine News Service Opinion material
„Gluten Sensitivity and Celiac Disease Dr. Tom O'Bryan's article, "The Conundrum of Gluten Sensitivity," published in the National Health Federation's publication, Health Freedom News, showed that he had done his homework concerning the newer diagnostic tests that are providing a new look at gluten sensitivity as well as out-and-out celiac disease. He also described signs and symptoms of celiac disease outside the intestinal tract, which broadens its scope. I wish to provide a different slant on the subject that is derived from a pediatric point of view that extends from old time through current technological advances.”Gluten Sensitivity and Celiac Disease Dr. Tom O'Bryan's article, "The Conundrum of Gluten Sensitivity," published in the National Health Federation's publication, Health Freedom News, showed that he had done his homework concerning the newer diagnostic tests that are providing a new look at gluten sensitivity as well as out-and-out celiac disease. He also described signs and symptoms of celiac disease outside the intestinal tract, which broadens its scope. I wish to provide a different slant on the subject that is derived from a pediatric point of view that extends from old time through current technological advances.
Orthomolecular Medicine News Service Opinion material
„Effect of gliadin on permeability of intestinal biopsy explants from celiac disease patients and patients with non-celiac gluten sensitivity. Nutrients. 2015 Feb 27;7(3):1565–76. 31. Samsel A, Seneff S. Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance. Interdiscip Toxicol. 2013 Dec;6(4):159–84. 32. Seneff S, Morley WA, Hadden MJ, Michener MC. Does Glyphosate Acting as a Glycine Analogue Contribute To ALS? Seneff [Internet].”Effect of gliadin on permeability of intestinal biopsy explants from celiac disease patients and patients with non-celiac gluten sensitivity. Nutrients. 2015 Feb 27;7(3):1565–76. 31. Samsel A, Seneff S. Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance. Interdiscip Toxicol. 2013 Dec;6(4):159–84. 32. Seneff S, Morley WA, Hadden MJ, Michener MC. Does Glyphosate Acting as a Glycine Analogue Contribute To ALS? Seneff [Internet].

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