Diet and nutritionPlant-Based Margarine — Healthier Than Butter for the Heart?
- Grażyna Cichosz — Kwasy tłuszczowe izomerii trans w diecie człowieka (Bromatologia i Chemia Toksykologiczna 2012)
- Ultra-processed Plant Foods: Are They Worse than their Unprocessed Animal-Based Counterparts? · Curr Nutr Rep 2025
- Theoretical Effects of Substituting Butter with Margarine on Risk of Cardiovascular Disease. · Epidemiology 2017
- Orthomolecular Medicine News Service — Sugar Fraud
Grażyna Cichosz cites studies in which an equivalent intake of trans isomers was associated with a 10-fold higher risk of heart disease than an equivalent intake of saturated fatty acids.
- She also cites a study linking margarine consumption to a 66% higher likelihood of a heart attack.
- According to Cichosz, TFAs make up to 35% of the fatty acids in hard margarines and up to 20% in soft margarines.
- Natural trans isomers in milk fat and ruminant fat showed no association with coronary atherosclerosis.
What the authors write
In hard margarines, TFAs make up to 35% of the fatty acids, and in soft margarines up to 20%.
Grażyna Cichosz cites studies in which an equivalent intake of trans isomers was associated with a 10-fold higher risk of heart disease than an equivalent intake of saturated fatty acids.
Grażyna Cichosz cites a study that linked margarine consumption to a 66% higher likelihood of a heart attack.
Natural trans isomers found in milk fat and ruminant fat showed no association with coronary atherosclerosis.
Research from PubMed · Europe PMC
We selected 2 studies with the best, positive results. This is a selection, not a full review of all research.
Total number of studies on this topic in PubMed: 3.
The review indicates that replacing butter with soft margarine lowers total and LDL cholesterol and is associated with a lower risk of cardiovascular events and death.
Aim of the study: This review aims to compare the impact of unprocessed animal foods with ultra-processed plant-based alternatives, particularly plant-based milks, plant-based meat analogs, and margarine, on cardiometabolic risk factors, chronic diseases, and mortality.
Results: The ultra-processed food category is highly heterogeneous, encompassing products with varying ingredients and nutrient profiles. Plant-based milks, plant-based meat analogs, and margarine, typically classified as ultra-processed foods, differ markedly from their unprocessed animal-based counterparts: they do not contain cholesterol or heme iron, have lower concentrations of saturated fat, sulfur, and branched-chain amino acids, and provide dietary fiber, which is absent in animal-based foods. Replacing dairy milk with soymilk has been shown to reduce total cholesterol (TC), LDL cholesterol (LDL-C), and C-reactive protein (CRP), and is associated with a lower risk of breast cancer. Compared to unprocessed animal-based products, plant-based meat analogs are associated with reductions in TC, LDL-C, body weight, plasma ammonia, and trimethylamine oxide (TMAO).
“Not stated” does not mean nobody paid — the database does not always record it.
The analysis found that replacing butter with tub margarine was associated with a lower risk of heart attack.
Aim of the study: Several recent articles have called into question the deleterious effects of high animal fat diets due to mixed results from epidemiologic studies and the lack of clinical trial evidence in meta-analyses of dietary intervention trials.
Results: Substituting butter or stick margarine with tub margarine was associated with lower risk of MI (HRs = 0.95 and 0.91). Subgroup analyses, which evaluated these substitutions among participants with a single source of spreadable fat, showed stronger associations for MI (HRs = 0.92 and 0.87). Outcomes of total CHD, ischemic stroke, and atherosclerosis-related CVD showed wide confidence intervals but the same trends as the MI results. This theoretical dietary substitution analysis suggests that substituting butter and stick margarine with tub margarine when spreadable fats are eaten may be associated with reduced risk of myocardial infarction.
“Not stated” does not mean nobody paid — the database does not always record it.
Perspectives and opinion materials
The content below presents the authors’ opinions, interpretations and hypotheses. It is not treated as equal to scientific studies and systematic reviews.
Pisaczek does not judge who is right. It shows what was written and where to read it. Every sentence above has its source.