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Diet and nutrition

Meat-based or vegan diet—which one really wins for health?

Sources: 12 · Article: 16 553 characters

Nathan S. Bryan believes that a meat-based diet may improve insulin sensitivity, promote weight loss and muscle gain, and reduce inflammation.

  • There is no single diet that works the same way for everyone; people differ in many ways, including their metabolism and microbiome.
  • M. Williamson, N. Moustaid-Moussa, and L. Gollahon emphasize that meat provides complete protein, iron, zinc, and vitamins B12 and B6.
  • Combining plant and animal foods, along with a varied and well-planned diet, may help support the body's balance.

What the authors write

Nathan S. Bryan

There is no single diet that works the same way for everyone; people differ in many ways, including their metabolism and microbiome.

„First, let me say there is no one diet that works the same in everyone. We all have different rates of metabolism, we all have a different microbiome and different species of bacteria that perform specific functions for us including metabolism of important nutrients from our food.”First, let me say there is no one diet that works the same in everyone. We all have different rates of metabolism, we all have a different microbiome and different species of bacteria that perform specific functions for us including metabolism of important nutrients from our food.
Nathan S. Bryan

A meat-based diet may improve insulin sensitivity, promote weight loss and muscle gain, and reduce inflammation.

„The carnivore diet has shown to improve insulin sensitivity, weight loss, increase muscle mass and lower inflammation. In this situation, the animal, which is vegan, consumes the plants and acts as a bioreactor converting the nutrients from their plant-based diet into their muscles.”The carnivore diet has shown to improve insulin sensitivity, weight loss, increase muscle mass and lower inflammation. In this situation, the animal, which is vegan, consumes the plants and acts as a bioreactor converting the nutrients from their plant-based diet into their muscles.
M. Williamson i N. Moustaid-Moussa i L. Gollahon

Meat is a source of complete protein, iron, zinc, and vitamins B12 and B6.

„Meat is nutrient dense, a good source of quality protein, Iron, Zinc, and Vitamins B12 and B6 (). Lean and unprocessed/fresh meats added into a well-balanced diet provides many nutritional and metabolic benefits, of which the mechanisms of action are just now being elucidated—challenging past paradigms.”Meat is nutrient dense, a good source of quality protein, Iron, Zinc, and Vitamins B12 and B6 (). Lean and unprocessed/fresh meats added into a well-balanced diet provides many nutritional and metabolic benefits, of which the mechanisms of action are just now being elucidated—challenging past paradigms.
M. Williamson i N. Moustaid-Moussa i L. Gollahon

Combining plant and animal foods may help support the body's balance, while a varied and well-planned diet may limit negative effects.

„Evidence suggests digestion of animal (oxidant) and plant (antioxidant) components together in the stomach is more beneficial to maintain redox homeostasis than meat with antioxidant supplementation (). Addition of garlic into ground beef reduced oxidation and improved color and microbial safety ().”Evidence suggests digestion of animal (oxidant) and plant (antioxidant) components together in the stomach is more beneficial to maintain redox homeostasis than meat with antioxidant supplementation (). Addition of garlic into ground beef reduced oxidation and improved color and microbial safety ().
M. Williamson i N. Moustaid-Moussa i L. Gollahon

M. Williamson, N. Moustaid-Moussa, and L. Gollahon believe that a healthy diet may vary from person to person.

„Public health, in all aspects, can benefit from continued promotion of a healthful diet, but with careful consideration for the definition of diet. With so many variables involved in the nourishment of the human body and mammalian cells, a healthful diet may be slightly different for everyone, like the differences between individuals in DNA.”Public health, in all aspects, can benefit from continued promotion of a healthful diet, but with careful consideration for the definition of diet. With so many variables involved in the nourishment of the human body and mammalian cells, a healthful diet may be slightly different for everyone, like the differences between individuals in DNA.

Research from PubMed · Europe PMC

We selected 7 studies with the best, positive results. This is a selection, not a full review of all research.

Total number of studies on this topic in PubMed: 158.

A meta-analysis found that a vegetarian diet lowered total and LDL cholesterol, but also HDL cholesterol.

Aim of the study: High blood lipids, blood glucose, or blood pressure ("3Bs") are established risk factors for cardiovascular diseases. However, the effects of vegetarian diets on these parameters were inconsistent in previous meta-analyses.

Results: The results showed that the vegetarian diets significantly reduced the blood total cholesterol [WMD: -0.54 (95% CI: -0.60, -0.48) mmol L-1, p < 0.001 for observational studies; WMD: -0.24 (95% CI -0.37, -0.10) mmol L-1, p < 0.001 for RCTs], low-density lipoprotein cholesterol [WMD: -0.41 (95% CI: -0.48, -0.34) mmol L-1, p < 0.001 for observational studies; WMD: -0.25 (95% CI: -0.38, -0.12) mmol L-1, p < 0.001 for RCTs], and high-density lipoprotein cholesterol [WMD: -0.07 (95% CI: -0.09, -0.05) mmol L-1, p < 0.001 for observational studies; WMD: -0.07 (95% CI: -0.11, -0.04) mmol L-1, p < 0.001 for RCTs] level compared with the omnivorous diet in both healthy subjects and subjects with chronic diseases, while it had a null effect on the blood triglyceride level.

Money for the studygovernment, public institutions · National Natural Science Foundation of China, Natural Science Foundation of Shandong Province
Do the authors have ties to companies?not stated
Did a manufacturer help with the study?unknown
Type of studycombined analysis of many studies (meta-analysis)

“Not stated” does not mean nobody paid — the database does not always record it.

Scientific guidance indicates that plant-based and vegetarian diets reduce the risk of cardiovascular disease.

Aim of the study: What we eat is a cornerstone of cardiovascular disease (CVD) prevention, but health professionals may not have a clear understanding of the current evidence-based research to underpin eating habits and recommendations.

Results: The consumption of one unit of alcohol/day may contribute to a reduced cardiovascular risk without presenting an unfavourable risk profile. Generally, there is no evidence that vitamin and mineral supplementation reduces CVD risk. High potassium intake is beneficial in healthy individuals, calcium or selenium supplementation shows no added benefit, and high sodium intake is detrimental. Diet is a major component of CVD prevention, and health professionals should include dietary assessment and evidence-based recommendations in their clinical practice.

Money for the studynot stated
Do the authors have ties to companies?not stated
Did a manufacturer help with the study?unknown
Type of studyother

“Not stated” does not mean nobody paid — the database does not always record it.

A review reports that plant-based diets were associated with a lower risk of coronary artery disease than non-vegetarian diets.

Aim of the study: Coronary artery disease (CAD), a primary component of cardiovascular diseases, is one of the top contributors to mortality rates worldwide. In 2021, dietary risk was estimated to be attributed to 6.58 million cardiovascular deaths.

Results: To ensure the accuracy and reliability of our review, we included a total of 55 full-text, peer-reviewed articles that demonstrated the effects of plant-based diets on CAD and were written in English. We excluded animal studies, in vitro or molecular studies, and non-original data like editorials, letters, protocols, and conference abstracts. In this article, we emphasize the importance of dietary interventions, such as PBDs, to prevent CAD and their benefits on environmental sustainability. Integrating plant foods and whole grains into one's daily eating habits leads to an increase in the intake of nutrient-rich foods while reducing the consumption of processed food could not only prevent millions of premature deaths but also provide prevention against many chronic gastrointestinal and metabolic diseases.

Money for the studynot stated
Do the authors have ties to companies?no — the authors say so
Did a manufacturer help with the study?NO
Type of studydiscussion of other studies

“Not stated” does not mean nobody paid — the database does not always record it.

A review indicates that a vegan diet is associated with beneficial changes in several cardiovascular risk factors, although it may provide lower amounts of some nutrients.

Aim of the study: The vegan diet, often known as a plant-rich diet, consists primarily of plant-based meals. This dietary approach may be beneficial to one's health and the environment and is valuable to the immune system.

Results: In comparison to omnivorous diets, which are often lower in such products, the vegan diet has been favorably connected with changes in cardiovascular disease (CVD) risk markers such as reduced body mass index (BMI) values, total serum cholesterol, serum glucose, inflammation, and blood pressure. Reduced intake of low-density lipoprotein (LDL), saturated fat, processed meat, and greater consumption of fiber and phytonutrients may improve cardiovascular health. However, vegans have much smaller amounts of nutrients such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), selenium, zinc, iodine, and vitamin B12, compared to non-vegans, which may lead to detrimental cardiovascular effects. This review aims to present the effect of plant-based diets (PBDs), specifically vegan diets, on the cardiovascular system.

Money for the studynot stated
Do the authors have ties to companies?not stated
Did a manufacturer help with the study?unknown
Type of studydiscussion of other studies

“Not stated” does not mean nobody paid — the database does not always record it.

A review of studies from Poland indicates that a vegetarian diet may help limit obesity risk and promote healthy cholesterol, blood sugar, and blood pressure.

Aim of the study: The first mention of a vegetarian diet in Poland appeared in the 19th century. Since then, its popularity has been growing steadily year by year.

Results: Such kind of nutrition based mainly on plant-derived products can effectively prevent diseases of civilization, reduce the risk of developing obesity, promote the maintenance of normal cholesterol and blood sugar, and lower blood pressure. However, an incorrectly balanced vegetarian diet may be associated with deficiencies of some vitamins and minerals. This paper reviews a few dozens of studies on people using a vegetarian diet in Poland. This review shows that vegetarians in Poland are not very well studied group and further research is needed.

Money for the studynot stated
Do the authors have ties to companies?not stated
Did a manufacturer help with the study?unknown
Type of studydiscussion of other studies

“Not stated” does not mean nobody paid — the database does not always record it.

A review indicates that healthy plant-based diets are associated with a lower risk of type 2 diabetes and better blood glucose control, while higher consumption of red and processed meat is associated with higher risk.

Aim of the study: Background: Type 2 diabetes mellitus (T2D) is one of the fastest-growing chronic diseases worldwide, affecting an estimated 589 million adults in 2024, with projections rising to 853 million by 2050. Dietary modification is a cornerstone of both T2D prevention and management.

Results: The interpretation of the available evidence is limited by the predominance of observational studies, heterogeneous definitions of plant-based dietary patterns, self-reported dietary assessments, and the limited availability of long-term randomized controlled trials. Conclusions: Current evidence supports healthy plant-based dietary patterns as an effective strategy for the prevention and management of T2D. Dietary patterns emphasizing whole plant foods, including legumes, whole grains, fruits, vegetables, nuts, and seeds, while limiting processed and excessive red meat intake, are associated with improved metabolic health. Future high-quality randomized controlled trials with standardized dietary definitions are needed to further define the optimal composition of plant-based diets for diabetes prevention and treatment.

Money for the studynot stated
Do the authors have ties to companies?no — the authors say so
Did a manufacturer help with the study?NO
Type of studydiscussion of other studies

“Not stated” does not mean nobody paid — the database does not always record it.

A review indicates that plant-based diets are associated with more favorable cardiometabolic health markers, even though some people have slightly lower HDL levels.

Aim of the study: Plant-based dietary patterns are associated with improved cardiometabolic health, including lower concentrations of serum low-density lipoprotein cholesterol, blood pressure, adiposity, inflammation, and lower risk of cardiovascular disease.

Results: We describe plausible mechanistic pathways, including lower saturated fat and cholesterol intake, reduced apolipoprotein A-I secretion and HDL production, and formation of smaller HDL particles that are cleared more rapidly. We suggest that modest HDL cholesterol reductions observed with healthy and appropriately planned plant-based diets should be interpreted within the broader context of net cardiometabolic benefit rather than as an isolated reason for clinical concern. However, substantial heterogeneity across studies-in both results and methodology, including variation in the definitions of plant-based diets-limits causal directionality and interpretation of reported diet-disease associations. Future analyses should improve diet classification and comparator selection, while controlling for weight change and macronutrient composition to isolate any potential effects of plant-based diets on HDL-related outcomes.

Money for the studynot stated
Do the authors have ties to companies?not stated
Did a manufacturer help with the study?unknown
Type of studydiscussion of other studies

“Not stated” does not mean nobody paid — the database does not always record it.

Perspectives and opinion materials

The content below presents the authors’ opinions, interpretations and hypotheses. It is not treated as equal to scientific studies and systematic reviews.

Orthomolecular Medicine News Service Opinion material
„Apparently, "You can still fit a daily serving of red meat into a healthy diet." [1] Really? A "daily serving" is considered to be about three ounces. Awesome! I get to eat three ounces of red meat a day! Wait, didn't the Harvard study just say that three ounces of red meat a day was killing people? Did the author read his own article?”Apparently, "You can still fit a daily serving of red meat into a healthy diet." [1] Really? A "daily serving" is considered to be about three ounces. Awesome! I get to eat three ounces of red meat a day! Wait, didn't the Harvard study just say that three ounces of red meat a day was killing people? Did the author read his own article?
Orthomolecular Medicine News Service Opinion material
„In 2018, WHO also called for the worldwide elimination of trans-fats by 2023, estimating 500,000 deaths per year result from the consumption of industrially produced trans-fatty acids. [11] Of note, increased magnesium intake is helpful in reducing the risks associated with consumption of artificial trans-fats. [12] However, avoiding any consumption of those "poisons" is best. 100 year old Dr. Kummerow shared his personal diet in a 2014 interview celebrating his 100th birthday. He died in 2017 at the age of 102. Passwater: What about your personal diet? Kummerow: I eat an egg every day and drink three glasses of whole milk.”In 2018, WHO also called for the worldwide elimination of trans-fats by 2023, estimating 500,000 deaths per year result from the consumption of industrially produced trans-fatty acids. [11] Of note, increased magnesium intake is helpful in reducing the risks associated with consumption of artificial trans-fats. [12] However, avoiding any consumption of those "poisons" is best. 100 year old Dr. Kummerow shared his personal diet in a 2014 interview celebrating his 100th birthday. He died in 2017 at the age of 102. Passwater: What about your personal diet? Kummerow: I eat an egg every day and drink three glasses of whole milk.
Orthomolecular Medicine News Service Opinion material
„A brief history of meat in the human diet and current health implications. Meat Sci. 2018 Oct;144:169–79. 60. Gorbunova NA. Assessing the role of meat consumption in human evolutionary changes. A review. Theory Pract Meat Process. 2024 Apr 2;9(1):53–64. 61. Larsen CS. Animal source foods and human health during evolution.”A brief history of meat in the human diet and current health implications. Meat Sci. 2018 Oct;144:169–79. 60. Gorbunova NA. Assessing the role of meat consumption in human evolutionary changes. A review. Theory Pract Meat Process. 2024 Apr 2;9(1):53–64. 61. Larsen CS. Animal source foods and human health during evolution.

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