Vitamins and mineralsVitamin B15 — a banned vitamin or a forgotten treasure?
- Jerzy Zięba — Witamina B15 - dimetyloglicyna
- Henryk Różański — Leki cyjanogenne w dawnej medycynie i witamina B17
- N, N-Dimethylglycine decreases oxidative stress and improves in vitro development of bovine embryos. · J Reprod Dev 2016
- Orthomolecular Medicine News Service — Niacin Was, Is, and Always will be Essential to Life and the Prevention of Cardiovascular Disease, Just for Starters
- Orthomolecular Medicine News Service — Reigniting Hope: Managing Systemic Lupus Erythematosus with Integrative Orthomolecular Medicine
- Orthomolecular Medicine News Service — Reboot Your Gut: Optimizing Health and Preventing Infectious Disease
Jerzy Zięba calls vitamin B15 dimethylglycine, or pangamic acid.
- Jerzy Zięba attributes several effects to it: a role in the body's reactions, faster oxidation of glucose and fats, improved circulation, support for the immune system, and better concentration.
- Jerzy Zięba says it is recommended, among other things, for diseases of the skin, joints, and circulatory system, but evidence of its effectiveness is limited.
- It occurs naturally in some foods, including beef, brewer’s yeast, brown rice, and seeds; it is also available in tablet form.
- Henryk Różański points out that pangamic acid should not be confused with amygdalin, known as vitamin B17.
What the authors write
Jerzy Zięba
Dimethylglycine is called pangamic acid, or vitamin B15.
„Dimethylglycine is pangamic acid, known as vitamin B15. Vitamin B15 is a substance that occurs naturally in many foods. Sources of dimethylglycine include beef, brewer’s yeast, brown rice, pumpkin seeds, and sunflower seeds. Dimethylglycine is also available in forms such as”Dimetyloglicyna to kwas pangamowy zwany witaminą B15. Witamina B15 jest substancją naturalnie występującą w wielu pokarmach. Źródłem dimetyloglicyny są m.in. mięso wołowe, drożdże piwne, ryż brązowy, nasiona dyni i słonecznika. Dimetyloglicyna jest również dostępna pod postacią m.in.
Jerzy Zięba
Dimethylglycine occurs in some foods and is also available in tablets as an ingredient in supplements.
„Vitamin B15 is a substance that occurs naturally in many foods. Sources of dimethylglycine include beef, brewer’s yeast, brown rice, pumpkin seeds, and sunflower seeds. Dimethylglycine is also available in forms such as tablets as an ingredient in dietary supplements.”Witamina B15 jest substancją naturalnie występującą w wielu pokarmach. Źródłem dimetyloglicyny są m.in. mięso wołowe, drożdże piwne, ryż brązowy, nasiona dyni i słonecznika. Dimetyloglicyna jest również dostępna pod postacią m.in. tabletek jako element suplementów diety.
Jerzy Zięba
Dimethylglycine is credited with a role in biochemical reactions, faster oxidation of glucose and fats, widening of blood vessels, support for the immune system, and improved concentration.
„Dimethylglycine performs many important functions in the human body. These include taking part in many biochemical reactions, speeding up the oxidation of glucose and lipids, widening blood vessels and improving circulation in muscles and other tissues, supporting the immune system, and improving concentration.”Dimetyloglicyna pełni w ludzkim organizmie wiele ważnych funkcji, w tym m.in. bierze udział w wielu reakcjach biochemicznych, przyspiesza utlenianie glukozy i lipidów, rozszerza naczynia krwionośne poprawiając ukrwienie mięśni i innych tkanek, wspomaga funkcjonowanie układu odpornościowego i poprawia koncentrację.
Jerzy Zięba
Its use is recommended, among other things, for skin diseases, weakened immunity, joint diseases, circulatory system diseases, and alcoholism.
„The use of dimethylglycine is recommended for treating, among other things, skin diseases, weakened immunity, joint diseases, circulatory system diseases, and alcoholism. Available data on the safety and effectiveness of products containing vitamin B15 are limited.”Stosowanie dimetyloglicyny jest zalecane w leczeniu m.in. chorób skóry, stanów obniżonej odporności, chorób stawów, chorób układu krążenia i alkoholizmu. Dostępne dane dotyczące bezpieczeństwa i skuteczności stosowania preparatów zawierających witaminę B15 są ograniczone.
Jerzy Zięba
Data on the safety and effectiveness of vitamin B15 products are limited.
„skin diseases, weakened immunity, joint diseases, circulatory system diseases, and alcoholism. Available data on the safety and effectiveness of products containing vitamin B15 are limited. It has been found that taking vitamin B15 at a dose of 50–100 mg/day does not have a toxic effect on the human body.”chorób skóry, stanów obniżonej odporności, chorób stawów, chorób układu krążenia i alkoholizmu. Dostępne dane dotyczące bezpieczeństwa i skuteczności stosowania preparatów zawierających witaminę B15 są ograniczone. Stwierdzono, że przyjmowanie witaminy B15 w dawce 50-100 mg/dzień nie oddziałuje toksycznie na organizm człowieka.
Jerzy Zięba
The description states that a dose of 50–100 mg per day does not have a toxic effect on the human body.
„skin diseases, weakened immunity, joint diseases, circulatory system diseases, and alcoholism. Available data on the safety and effectiveness of products containing vitamin B15 are limited. It has been found that taking vitamin B15 at a dose of 50–100 mg/day does not have a toxic effect on the human body.”chorób skóry, stanów obniżonej odporności, chorób stawów, chorób układu krążenia i alkoholizmu. Dostępne dane dotyczące bezpieczeństwa i skuteczności stosowania preparatów zawierających witaminę B15 są ograniczone. Stwierdzono, że przyjmowanie witaminy B15 w dawce 50-100 mg/dzień nie oddziałuje toksycznie na organizm człowieka.
Henryk Różański
Amygdalin, known as vitamin B17, is not the same as vitamin B15, or pangamic acid.
„These claims are supported by many authors. It has not received a favorable opinion from the FDA. It occurs in the seeds of citrus fruits and plums, in almonds, and elsewhere. It should not be confused with vitamin B15, or pangamic acid.
More about vitamin B17: https://rozanski.li/?p=1340”Przesłanki te podtrzymywane są przez wielu autorów. Nie uzyskała pozytywnej opinii od FDA. Występuje w pestkach owoców cytrusowych, śliwek, w migdałach i in. Nie należy jej mylić z witaminą B15, czyli kwasem pangamowym (pangamic acid).
Więcej o witaminie B17: https://rozanski.li/?p=1340
Jerzy Zięba
The listed side effects of dimethylglycine include nausea and a higher risk of kidney stones; kidney disease may be a contraindication or may require a change in the amount taken.
„Some conditions, such as kidney disease, may be a contraindication to using products containing dimethylglycine or may indicate that the amount taken should be changed. The list of side effects associated with taking dimethylglycine includes nausea and an increased risk of kidney stones.”Niektóre choroby, np. choroby nerek mogą stanowić przeciwwskazanie do stosowania preparatów zawierających dimetyloglicynę lub wskazanie do zmiany spożywanej ilości. Lista działań niepożądanych związanych z przyjmowaniem dimetyloglicyny obejmuje m.in. nudności oraz podwyższone ryzyko tworzenia się kamieni nerkowych.
Jerzy Zięba
Dimethylglycine should be taken according to the package leaflet or a healthcare professional’s advice, and the daily amount stated for the supplement should not be exceeded.
„Dimethylglycine should be taken according to the instructions in the leaflet included with the product or as advised by a doctor, pharmacist, or nurse. Do not exceed the recommended daily amount of dietary supplements containing dimethylglycine.”Dimetyloglicynę należy przyjmować zgodnie z opisem w ulotce dołączonej do produktu lub według zaleceń wydanych przez lekarza, farmaceutę lub pielęgniarkę. Nie należy przekraczać zalecanej dziennej porcji suplementów diety zawierających dimetyloglicynę.
Research from PubMed · Europe PMC
We selected 1 studies with the best, positive results. This is a selection, not a full review of all research.
Total number of studies on this topic in PubMed: 1.
In bovine embryo culture, dimethylglycine had an antioxidant effect and improved their development to the blastocyst stage.
Aim of the study: The antioxidant effect of N, N-dimethylglycine (DMG) on in vitro-produced (IVP) bovine embryos was examined. After in vitro fertilization, presumptive zygotes were cultured with or without 0.1 μM DMG under different oxygen tensions.
Results: Furthermore, a tendentious increase (P = 0.06) in blastocyst cell numbers was observed when DMG was applied. In the second experiment, addition of H2O2 (0.5 mM) to the culture medium significantly (P < 0.01) reduced the percentage of embryos developing to the blastocyst stage. However, DMG supplementation prevented this reduction. In conclusion, DMG enhanced the invitro development of IVP bovine embryos by acting as an antioxidant.
N, N-Dimethylglycine decreases oxidative stress and improves in vitro development of bovine embryos. · J Reprod Dev 2016
Money for the studynot stated
Do the authors have ties to companies?not stated
Did a manufacturer help with the study?unknown
Type of studyanimal study
“Not stated” does not mean nobody paid — the database does not always record it.
Perspectives and opinion materials
The content below presents the authors’ opinions, interpretations and hypotheses. It is not treated as equal to scientific studies and systematic reviews.
Orthomolecular Medicine News Service Opinion material
„However, neither of these are NAD precursors, and so dimethyl fumarate is likely inferior and Tecfidera is more expensive, while beta alanine is a precursor to vitamin B5, so it has additional benefits that have yet to be fully characterized and understood. The data on immediate-release (standard grocery store) niacin remains an unparalleled success in the history of cardiovascular disease trial outcomes. [7,27,28] There is no question about the benefits of plain immediate-release niacin (IRN). While extended-release niacin (ERN/Niaspan) from 1955-1998 may have drawbacks, it is therapeutically beneficial.”However, neither of these are NAD precursors, and so dimethyl fumarate is likely inferior and Tecfidera is more expensive, while beta alanine is a precursor to vitamin B5, so it has additional benefits that have yet to be fully characterized and understood. The data on immediate-release (standard grocery store) niacin remains an unparalleled success in the history of cardiovascular disease trial outcomes. [7,27,28] There is no question about the benefits of plain immediate-release niacin (IRN). While extended-release niacin (ERN/Niaspan) from 1955-1998 may have drawbacks, it is therapeutically beneficial.
Orthomolecular Medicine News Service Opinion material
„3-[(2,4-dihydroxy-3,3-dimethylbutanoyl)amino]propanoic acid (Vitamin B5): Its Synthesis, Transformation into Coenzyme A and Role in Disease. UTSCs J Nat Sci. 2(1):102-15. 93. Minami Y, Hirabayashi Y, Nagata C, Ishii T, Harigae H, Sasaki T. Intakes of vitamin B6 and dietary fiber and clinical course of systemic lupus erythematosus: a prospective study of Japanese female patients. J Epidemiol. 2011;21(4):246-54. 94. Mikkelsen K, Dargahi N, Fraser S, Apostolopoulos V.”3-[(2,4-dihydroxy-3,3-dimethylbutanoyl)amino]propanoic acid (Vitamin B5): Its Synthesis, Transformation into Coenzyme A and Role in Disease. UTSCs J Nat Sci. 2(1):102-15. 93. Minami Y, Hirabayashi Y, Nagata C, Ishii T, Harigae H, Sasaki T. Intakes of vitamin B6 and dietary fiber and clinical course of systemic lupus erythematosus: a prospective study of Japanese female patients. J Epidemiol. 2011;21(4):246-54. 94. Mikkelsen K, Dargahi N, Fraser S, Apostolopoulos V.
Orthomolecular Medicine News Service Opinion material
„Two substances that are especially effective in stripping away biofilms to permit the effective application of anti-pathogen measures are hydrogen peroxide and dimethyl sulfoxide (DMSO). [66-69] When dealing with chronic conditions in the sinuses and pharynx, it is probably best to first nebulize with hydrogen peroxide (1 to 5 cc of 3% peroxide with volume brought up to 10 to 12 cc with filtered water) for about 15 minutes or so, and then follow with nebulization of any of a number of other agents. Alternatively, DMSO can be readily combined with other anti-pathogen agents, such as sodium ascorbate (vitamin C) and magnesium chloride.”Two substances that are especially effective in stripping away biofilms to permit the effective application of anti-pathogen measures are hydrogen peroxide and dimethyl sulfoxide (DMSO). [66-69] When dealing with chronic conditions in the sinuses and pharynx, it is probably best to first nebulize with hydrogen peroxide (1 to 5 cc of 3% peroxide with volume brought up to 10 to 12 cc with filtered water) for about 15 minutes or so, and then follow with nebulization of any of a number of other agents. Alternatively, DMSO can be readily combined with other anti-pathogen agents, such as sodium ascorbate (vitamin C) and magnesium chloride.
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