Vitamins and mineralsLiposomal vitamin C — breakthrough or marketing gimmick?
Sources: 9 · Article: 14 258 characters
Jerzy Zięba says that ordinary vitamin C works better than liposomal vitamin C during an infection.
- Andrzej Frydrychowski calls liposomal vitamin C the most absorbable form and says it may be absorbed at a rate of 90 percent, compared with around 60 percent for traditional vitamin C.
- According to Frydrychowski, liposomes protect the vitamin and allow it to be released slowly and absorbed in the small intestine.
- Zięba describes the homemade preparation as an emulsion, not liposomes, and writes that the price of genuine liposomal vitamin C is prohibitive for many people.
What the authors write
Andrzej Frydrychowski
Andrzej Frydrychowski calls liposomal vitamin C the most absorbable form and describes it as vitamin C enclosed in a lipid coating.
„Liposomal vitamin C, meaning vitamin C molecules enclosed in a lipid coating, is the most absorbable form of this vitamin. It is enclosed in liposomes, which are microscopic lipid vesicles (phospholipid capsules) whose structure resembles cell membranes.”Liposomalna witamina C, czyli cząsteczki witaminy C w otoczce lipidowej, to najlepiej przyswajalna postać tej witaminy. Została ona zamknięta w liposomach, czyli w mikroskopijnej wielkości pęcherzykach lipidowych (kapsułkach fosfolipidowych), których budowa przypomina błony komórkowe.
Andrzej Frydrychowski
Andrzej Frydrychowski claims that liposomes protect vitamin C and allow it to be released slowly and absorbed in the small intestine.
„Liposomes allow vitamin C to remain enclosed inside them for a long time in a stable form and to be absorbed efficiently, extending its therapeutic effect. Liposomal vitamin C releases the active substance very slowly, resulting in the body being supplied with it over an extended period.”Liposomy pozwalają na długotrwałe, stabilne zamknięcie witaminy C w ich wnętrzu oraz na jej efektywne wchłanianie, co wydłuża terapeutyczne działanie. Liposomalna witamina C uaktywnia substancję czynną bardzo powoli, a to skutkuje wysycaniem nią organizmu przez długi czas.
Andrzej Frydrychowski
Andrzej Frydrychowski says that liposomal vitamin C may be absorbed at a rate of 90 percent, compared with around 60 percent for traditional vitamin C.
„The high bioavailability of vitamin C, reaching as much as 90 percent (traditional vitamin C is absorbed at around 60 percent), guarantees a strong effect.
It seems only natural to add something else to a vitamin like this. HerbaSano has done just that.”Wysoka bioprzyswajalność witaminy C, wynosząca nawet 90 proc. (tradycyjna witamina C wchłania się w ok. 60 procentach) gwarantuje dużą skuteczność działania.
Aż się prosi, ażeby do takiej witaminy jeszcze coś dodać. Firma HerbaSano właśnie to zrobiła.
Andrzej Frydrychowski
Andrzej Frydrychowski lists slow release, effectiveness, and not irritating the stomach as advantages of this form of the vitamin.
„Its greatest advantages are slow release, effectiveness, and not irritating the stomach. The high bioavailability of vitamin C, reaching as much as 90 percent (traditional vitamin C is absorbed at around 60 percent), guarantees a strong effect.
It seems only natural to add something else to a vitamin like this.”Jej największą zaletą jest powolne uwalnianie, skuteczność i brak podrażnienia żołądka. Wysoka bioprzyswajalność witaminy C, wynosząca nawet 90 proc. (tradycyjna witamina C wchłania się w ok. 60 procentach) gwarantuje dużą skuteczność działania.
Aż się prosi, ażeby do takiej witaminy jeszcze coś dodać.
Andrzej Frydrychowski
The formula described by Andrzej Frydrychowski contains lecithin, vitamin C, plant extracts, and diosmin.
„The liposomal formula, which improves the absorption of its ingredients, contains lecithin, vitamin C, extracts from plants commonly known as natural sources of ascorbic acid, and diosmin (which increases venous tone and protects blood vessels). At the level of the veins, it reduces vein dilation and venous stasis.”Liposomalna formuła, która poprawia wchłanianie składników, zawiera: lecytynę, witaminę C, ekstrakty z roślin powszechnie znanych jako naturalne źródła kwasu askorbinowego oraz diosminę (zwiększa ona napięcie żylne i działa ochronnie na naczynia). Na poziomie naczyń żylnych zmniejsza rozszerzalność żył oraz zastój żylny.
Andrzej Frydrychowski
Andrzej Frydrychowski recommends this formula for venous circulation disorders and their prevention.
„At the level of the veins, it reduces vein dilation and venous stasis. At the microcirculation level, it reduces capillary permeability and increases their resistance. In other words, we recommend it for all kinds of venous circulation disorders, as well as for their prevention.”Na poziomie naczyń żylnych zmniejsza rozszerzalność żył oraz zastój żylny. Zaś na poziomie mikrokrążenia zmniejsza przepuszczalność włośniczek i zwiększa ich opór). Czyli praktycznie polecamy ją we wszelkich zaburzeniach krążenia żylnego, jak również w ich profilaktyce.
Andrzej Frydrychowski
The capsule described by Andrzej Frydrychowski contains lecithin, L-ascorbic acid, plant extracts, and micronized diosmin.
„The ingredients in a HerbaSano liposomal vitamin C capsule are: lecithin (from sunflower seed oil), L-ascorbic acid (vitamin C), rosehip extract (standardized to 10 percent vitamin C), Malpighia glabra extract (standardized to 16 percent vitamin C), diosmin (micronized), camu camu extract (standardized to 54 percent vitamin C), and tannin plant leaf extract (standardized to 1.5 percent vitamin C). Let us summarize what each ingredient in the capsule affects.”Składniki kapsułki witaminy C liposomalnej HerbaSano to: lecytyna (z oleju z nasion słonecznika), kwas L- askorbinowy (witamina C), ekstrakt z dzikiej róży (standaryzowany na 10 proc. witaminy C), ekstrakt z malpigii granatolistnej (standaryzowany na 16 proc. witaminy C), diosmina (zmikronizowana), ekstrakt z camu camu (standaryzowany na 54 proc. witaminy C), ekstrakt liściokwiatu garbnikowego (standaryzowany na 1,5 proc. witaminy C).Podsumujmy więc, na co wpływają poszczególne składniki kapsułki.
Jerzy Zięba
Jerzy Zięba describes the direct release of the vitamin from the liposome into the cell as a theory.
„That is the theory. The direct release of vitamin C into the cell certainly makes a lot of sense, especially in cases of cancer. However, my experience in this area indicates that non-liposomal vitamin C works better for infections.”Taka jest teoria. Bezpośrednie uwalnianie witaminy C do komórki ma oczywiście bardzo dużo sensu, szczególnie w przypadkach nowotworów. Moje doświadczenie w tym zakresie wskazuje jednak na to, że w infekcjach lepiej sprawdza się witamina C, która nie jest w formie liposomalnej.
Jerzy Zięba
Jerzy Zięba says that non-liposomal vitamin C works better for infections.
„However, my experience in this area indicates that non-liposomal vitamin C works better for infections. This may be due to the QUALITY of the vitamin in liposomal form. It should be mentioned here that many descriptions can be found online of how to make liposomal vitamin C at home using devices that are popular ultrasonic cleaners.”Moje doświadczenie w tym zakresie wskazuje jednak na to, że w infekcjach lepiej sprawdza się witamina C, która nie jest w formie liposomalnej. Może to wynikać z JAKOŚCI wita- miny w formie liposomalnej. Należy tu wspomnieć o tym, że w Internecie znajdziemy wiele opisów domowego sposobu produkowania liposomalnej witaminy C w urządzeniach, które są popularnymi myjkami ultradźwiękowymi.
Jerzy Zięba
Jerzy Zięba describes the homemade preparation as an emulsion, not liposomes.
„I started making this “liposomal” vitamin myself around 10 years ago, but it turned out that it was not liposomes, but an emulsion—and that is something completely different. So far, I know only one company (from the USA) that can truly produce liposomal vitamin C.”Taką witaminę „liposomalną” zacząłem sam wytwarzać ok. 10 lat temu, ale okazało się, że to nie były liposomy, tylko emulsja – a to jest zupełnie coś innego. Znam do tej pory tylko jedną firmę (z USA), która naprawdę po- trafi wyprodukować liposomalną witaminę C.
Jerzy Zięba
Jerzy Zięba writes that he knows one company that makes genuine liposomal vitamin C and that its price is prohibitive for many people.
„So far, I know only one company (from the USA) that can truly produce liposomal vitamin C. It is now available in Poland, but… the price is simply prohibitive for many people.
Finally, it should be said that taking vitamin C preventively is extremely valuable, not only because it helps build the body’s resistance to colds.”Znam do tej pory tylko jedną firmę (z USA), która naprawdę po- trafi wyprodukować liposomalną witaminę C. Jest już ona osiągalna w Polsce, ale… cena dla wielu osób jest po prostu zaporowa.
Na koniec należy powiedzieć, że stosowanie wita- miny C profilaktycznie jest niezwykle cenne nie tylko ze względu na budowanie odporności organizmu na przeziębienia.
Research from PubMed · Europe PMC
We selected 4 studies with the best, positive results. This is a selection, not a full review of all research.
Total number of studies on this topic in PubMed: 487.
The review found that 9 out of 10 studies reported greater bioavailability for liposomal vitamin C, although evidence of biological effects is limited.
Aim of the study: Due to the essential requirement of vitamin C (ascorbate) by humans, formulation of the vitamin to increase its bioavailability is of relevance, particularly for those with higher requirements for the vitamin. In this scoping review, studies assessing the bioavailability of liposomal versus non-liposomal ascorbate were identified through database and manual searching and relevant pharmacokinetic data were extracted.
Results: In this review, studies assessing the uptake of liposomal versus non-liposomal vitamin C were investigated; liposomal vitamin C comprising the vitamin encapsulated within lipids. Ten studies were identified, which administered different liposomal formulations, vitamin C doses (0.15-10 g) and sample collection durations (4-24 h). Nine of the studies showed higher uptake of liposomal vitamin C. Future studies should assess urinary excretion, cellular uptake and biological effects of liposomal vitamin C.
Money for the studynot stated
Do the authors have ties to companies?no — the authors say so
Did a manufacturer help with the study?NO
Type of studydiscussion of other studies
“Not stated” does not mean nobody paid — the database does not always record it.
In a randomized study, liposomal vitamin C increased vitamin C levels in plasma and leukocytes more than ordinary vitamin C.
Aim of the study: L-Ascorbic acid (vitamin C) is an essential water-soluble vitamin that plays an important role in various physiological functions, including immune health. The stability of vitamin C in the gastrointestinal tract its bioavailability is limited. This study aimed to investigate if a liposomal form of vitamin C can increase absorption compared to standard vitamin C.
Results: VIT C and LV-VIT C demonstrated significantly greater Cmax and AUC0 - 24 in plasma and in leukocytes compared to placebo (p < 0.001). Additionally, LV-VIT C had significantly higher Cmax (plasma + 27%, leukocytes + 20%, p < 0.001) and AUC0 - 24 (plasma + 21%, leukocytes + 8%, p < 0.001) values as compared to VIT C. Liposomal formulation of vitamin C increases absorption into plasma and leukocytes.
Money for the studycompany or manufacturer · SpecNova LLC
Do the authors have ties to companies?no — the authors say so
Did a manufacturer help with the study?YES
Type of studystudy with random allocation to groups (RCT)
Participants27
“Not stated” does not mean nobody paid — the database does not always record it.
The study found that liposomal vitamin C had 1.77 times greater bioavailability than vitamin C without liposomes.
Aim of the study: The aim of this study was to evaluate the oral bioavailability of liposomal vitamin C and non-liposomal vitamin C in healthy, adult, human subjects under fasting conditions through an open label, randomized, single-dose, two-treatment, two-sequence, two-period, two-way crossover, study.
Results: The results of the clinical studies of liposomal vitamin C by oral delivery to be 1.77 times more bioavailable than non-liposomal vitamin C. The liposomal vitamin C demonstrated higher values of Cmax, AUC0-t and AUC0-∞ related to non-liposomal vitamin C due to liposomal encapsulation. No adverse events were reported. It could be concluded that liposomal encapsulated ascorbic acid (vitamin C) shows well-organized morphological pattern, uniform particle size and highly efficient, which leads to have enhanced bioavailability.
Money for the studynot stated
Do the authors have ties to companies?not stated
Did a manufacturer help with the study?unknown
Type of studystudy with random allocation to groups (RCT)
“Not stated” does not mean nobody paid — the database does not always record it.
Participants in the study achieved higher blood vitamin C levels after taking oral liposomal vitamin C than after taking ordinary oral vitamin C.
Aim of the study: Intravenous administration of vitamin C has been shown to decrease oxidative stress and, in some instances, improve physiological function in adult humans. Oral vitamin C administration is typically less effective than intravenous, due in part to inferior vitamin C bioavailability.
Results: Oral vitamin C administration is typically less effective than intravenous, due in part to inferior vitamin C bioavailability. The purpose of this study was to determine the efficacy of oral delivery of vitamin C encapsulated in liposomes. On 4 separate randomly ordered occasions, 11 men and women were administered an oral placebo, or 4 g of vitamin C via oral, oral liposomal, or intravenous delivery. The data indicate that oral delivery of 4 g of vitamin C encapsulated in liposomes (1) produces circulating concentrations of vitamin C that are greater than unencapsulated oral but less than intravenous administration and (2) provides protection from ischemia-reperfusion-mediated oxidative stress that is similar to the protection provided by unencapsulated oral and intravenous administrations.
Money for the studycompany or manufacturer · Empirical Labs
Do the authors have ties to companies?yes — the authors reported it
Did a manufacturer help with the study?YES
Type of studyclinical study in people
Participants11
“Not stated” does not mean nobody paid — the database does not always record it.
Perspectives and opinion materials
The content below presents the authors’ opinions, interpretations and hypotheses. It is not treated as equal to scientific studies and systematic reviews.
Orthomolecular Medicine News Service Opinion material
„[29] Liposomal C Liposomal vitamin C is absorbed by a different mechanism in the gut. The liposomes containing vitamin C can bind directly to the gut cells to release their content of vitamin C which therefore does not require active transport. Thus the maximum level achievable with oral doses of liposomal vitamin C is higher than for regular vitamin C.”[29] Liposomal C Liposomal vitamin C is absorbed by a different mechanism in the gut. The liposomes containing vitamin C can bind directly to the gut cells to release their content of vitamin C which therefore does not require active transport. Thus the maximum level achievable with oral doses of liposomal vitamin C is higher than for regular vitamin C.
Orthomolecular Medicine News Service Opinion material
„Since ascorbic acid is much cheaper than liposomal vitamin C, it is cost effective for a healthy person to start with ascorbic acid and top up with liposomes as required. When a person becomes ill they can absorb massive doses of standard ascorbic acid, using the dynamic flow approach. So if you are sick, taking a gram of liposomal vitamin C instead of a gram of cheap ascorbic acid will provide little extra benefit. Both will be well absorbed , and the liposome contains sodium ascorbate which is less effective. Liposomes only provide added benefit once the sick person has approached bowel tolerance levels, using standard ascorbic acid.”Since ascorbic acid is much cheaper than liposomal vitamin C, it is cost effective for a healthy person to start with ascorbic acid and top up with liposomes as required. When a person becomes ill they can absorb massive doses of standard ascorbic acid, using the dynamic flow approach. So if you are sick, taking a gram of liposomal vitamin C instead of a gram of cheap ascorbic acid will provide little extra benefit. Both will be well absorbed , and the liposome contains sodium ascorbate which is less effective. Liposomes only provide added benefit once the sick person has approached bowel tolerance levels, using standard ascorbic acid.
Orthomolecular Medicine News Service Opinion material
„Integrative Antioxidant Therapy Protocol (The following recommendations should be implemented under the supervision of a qualified healthcare provider): Vitamin C [5,6,100] : Vitamin C powder is fine, although Liposomal VC is preferred for its better absorption, especially for severe Covid-19 or other severe illnesses. High dose Intravenous vitamin C (30 g/day or higher) is great, although this requires a physician's supervision. If used early and in sufficient doses, the high dose regular vitamin C powder or good quality liposomal vitamin C suffice. Vitamin D3: regular vitamin D3 supplements available on the market should suffice.”Integrative Antioxidant Therapy Protocol (The following recommendations should be implemented under the supervision of a qualified healthcare provider): Vitamin C [5,6,100] : Vitamin C powder is fine, although Liposomal VC is preferred for its better absorption, especially for severe Covid-19 or other severe illnesses. High dose Intravenous vitamin C (30 g/day or higher) is great, although this requires a physician's supervision. If used early and in sufficient doses, the high dose regular vitamin C powder or good quality liposomal vitamin C suffice. Vitamin D3: regular vitamin D3 supplements available on the market should suffice.
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