Herbs and plantsCalendula — the golden flower that heals wounds better than pharmacy ointment?
- Henryk Różański — Kwiat nagietka – Flos Calendulae jako surowiec farmakopealny
- Henryk Różański — Nagietek – Calendula
- Effect of oral Calendula officinalis on second-degree burn wound healing. · Scars Burn Heal 2023
- Calendula officinalis extract enhances wound healing by promoting fibroblast activity and reducing inflammation in mice. · Cutan Ocul Toxicol 2025
- Calendula glycolic extract enhances wound healing of alginate hydrogel. · Acta Cir Bras 2024
- Polyacrylamide Hydrogel Containing Calendula Extract as a Wound Healing Bandage: In Vivo Test. · Int J Mol Sci 2023
Henryk Różański says that calendula helps wounds heal and has anti-inflammatory effects.
- An ointment with wound-healing and anti-inflammatory effects can be made from fresh flowering herb.
- An infusion of the herb and flowers can be used as a compress on wounds, and in the past, tincture was applied to wounds that were difficult to heal.
- Calendula ointment is sold in pharmacies, and the preparations mentioned are said to stimulate tissue regeneration.
What the authors write
Calendula helps wounds heal and has anti-inflammatory effects.
An ointment with wound-healing and anti-inflammatory effects can be made from fresh flowering herb.
An infusion of the herb and flowers can be used as a compress on wounds, and in the past, tincture was applied to wounds that were difficult to heal.
In traditional medicine, calendula tincture was used on wounds that were difficult to heal, pus-filled wounds, and weeping ulcers.
Calendula ointment is sold in pharmacies, and the preparations mentioned are said to stimulate tissue regeneration.
Research from PubMed · Europe PMC
We selected 4 studies with the best, positive results. This is a selection, not a full review of all research.
Total number of studies on this topic in PubMed: 110.
In a clinical study, oral calendula accelerated the healing of second-degree burns compared with a placebo.
Aim of the study: Treatment of wounds and burn injuries is very important. Nowadays, the tendency to research complementary medicine has increased.
Results: The mean total wound status scores using BWAT on days 1, 7, and 14 were 48.23, 35.93, and 22.97, respectively, in the intervention group, and 48.90, 42.57, and 37.8 in the control group. Statistically, wound condition on the first day was at the same level in both groups. Wound healing scores in the two groups improved during days 1 to 15 of the study (P <0.001). However, in the intervention group, the degree of wound healing changed on days 7 and 15 and was greater than in the control group. Based on the results of this study, C. officinalis may have beneficial healing properties and may be effective in accelerating the healing of second-degree burn wounds. It can be used as a supplement in wound treatment.
“Not stated” does not mean nobody paid — the database does not always record it.
In mice, calendula extract reduced wound area and increased processes involved in healing.
Aim of the study: Despite evidence supporting the therapeutic potential of Calendula officinalis, well-designed and controlled studies are still needed to confirm its beneficial effects on various health conditions, including skin care. This study therefore evaluates the effectiveness of topically administered 5% aqueous Calendula officinalis extract on healing full-thickness skin wounds in male BALB/c mice.
Results: The data obtained show that application of CAL extract significantly reduces wound area by day 7 compared with the NC and PSS groups. CAL extract also increases levels of fibroblasts, fibroblast growth factor, and hydroxyproline, while reducing macrophages and inflammatory biomarkers in the healing wound. Genomic analyses indicate that topical application of CAL extract significantly reduces the expression of inflammatory biomarkers, including matrix metalloproteinases 2 and 9. These findings show that 5% aqueous CAL extract enhances wound healing, offering promising new insights for the effective topical treatment of skin wounds.
“Not stated” does not mean nobody paid — the database does not always record it.
In rats, calendula hydrogel improved wound closure and promoted collagen deposition.
Aim of the study: To assess the cytotoxicity and wound healing properties of an alginate hydrogel containing calendula glycolic extract.
Results: Cytotoxicity tests on 3T3 cells revealed increased cell viability with the calendula-alginate hydrogel. The calendula-alginate hydrogel also significantly improved wound closure. Histopathological analysis supported this finding, showing reduced inflammation, increased macrophage activity, and greater collagen deposition. These findings demonstrated the therapeutic potential of combining calendula extract and alginate to promote enhanced wound healing.
“Not stated” does not mean nobody paid — the database does not always record it.
In rats, calendula hydrogel supported skin repair and collagen fiber production, with no signs of skin toxicity.
Aim of the study: Hydrogel is a biomaterial widely used in several areas of industry due to its great biocompatibility and adaptability to biological tissues. In Brazil, the Calendula plant is approved by the Ministry of Health as a medicinal herb.
Results: The morphology of the matrices showed large pores and a leaf-like structure. In vivo testing and evaluation of acute dermal toxicity were conducted using male Wistar rats. The tests indicated efficient collagen fiber production, improved skin repair, and no signs of dermal toxicity. Thus, the hydrogel has suitable properties for the controlled release of calendula extract when used as a dressing to promote healing.
“Not stated” does not mean nobody paid — the database does not always record it.
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