Peptides — the key to longevity or just another fad?

Sources: 4 · Article: 8 578 characters

Andrzej Frydrychowski — Peptydy – klucz do długowieczności
Soft-Shelled Turtle Peptides Extend Lifespan and Healthspan in Drosophila. · Nutrients 2022
Antioxidant Peptides Derived from Millet Bran Promote Longevity and Stress Resistance in Caenorhabditis elegans. · Plant Foods Hum Nutr 2023
Egg Peptides From American Shad Extend Lifespan and Healthspan in Caenorhabditis elegans via Lipid Metabolism Remodeling and Antioxidant Defense. · Chem Biodivers 2026

Andrzej Frydrychowski lists peptides among the keys to reaching the age of 100.

Peptides are said to increase growth hormone secretion and slow aging.
However, the reported extension of lifespan was demonstrated in studies on laboratory animals.
Andrzej Frydrychowski also emphasizes the role of natural peptides in regulating the body and maintaining health and good physical condition.

What the authors write

Andrzej Frydrychowski

Peptides are listed among the keys to reaching the age of 100.

„Scientists list peptides among the keys to reaching the age of 100. Brazilian doctors working in hospital burn units also make use of their remarkable properties. Meanwhile, products based on Biopeptide Complex, patented in Poland—a cocktail of bioactive fish collagen peptides—are said to deliver impressive anti-aging and health benefits and improve quality of life.”Wśród kluczy do osiągnięcia 100 lat naukowcy wymieniają peptydy. Ich niezwykłe właściwości wykorzystują również brazylijscy lekarze pracujący na szpitalnych oddziałach pooparzeniowych. Tymczasem preparaty na bazie opatentowanego w Polsce Biopeptide Complex, koktajlu bioaktywnych peptydów kolagenu rybiego przynoszą zachwycające efekty przeciwstarzeniowe, prozdrowotne i podnoszące jakość życia.

Peptydy – klucz do długowieczności

Andrzej Frydrychowski

Peptides are said to increase growth hormone secretion, support bone and muscle growth, and slow aging.

„Peptides, or bioactive chains of amino acids, increase the secretion of human growth hormone (HGH). They also support fat metabolism, bone growth, and muscle tissue growth. As was emphasized at the symposium, their remarkable properties can help us slow aging and not only live to an advanced age, but reach it in good health and excellent physical condition.”Peptydy, czyli bioaktywne łańcuchy aminokwasów, zwiększają wydzielanie ludzkiego hormonu wzrostu (HGH). Wspomagają również metabolizm tłuszczu, wzrost kości i przyrost tkanki mięśniowej. Jak podkreślano podczas sympozjum, dzięki ich niezwykłym właściwościom jesteśmy w stanie spowolnić starzenie się i nie tylko dożyć sędziwego wieku, ale i osiągnąć go, ciesząc się zdrowiem i świetną kondycją.

Peptydy – klucz do długowieczności

Andrzej Frydrychowski

Studies on laboratory animals indicate that regularly administering peptides can extend lifespan.

„Because protein production is essential for the functioning of organs and the whole body, we need a tool to stimulate cells to work in this area—peptides are that tool. Studies on laboratory animals show that regularly supplying their bodies with peptides leads to a longer lifespan, prevents carcinogenesis, and significantly improves kidney regeneration and the appearance of their fur.”Ponieważ wytwarzanie białka jest niezbędne do funkcjonowania organów i całego organizmu, potrzebujemy narzędzia, które pobudzi komórki do aktywności na tym polu – tym narzędziem są peptydy. Badania na zwierzętach laboratoryjnych dowodzą, iż regularne dostarczanie ich organizmom peptydów powoduje: wydłużenie życia, powstrzymanie kancerogenezy oraz znacząco poprawia regenerację nerek i wygląd sierści.

Peptydy – klucz do długowieczności

Andrzej Frydrychowski

Natural peptides are said to support the regulation of the body and help maintain health and good physical condition.

„WellU press office Peptides serve an important purpose: restoring disrupted homeostasis. They activate only the metabolic pathways needed at a given time, thanks to their natural characteristics. That is why regular, preventive use of products containing the biologically active, natural peptides in Biopeptide Complex is so beneficial for maintaining health and good physical condition.”prasowe WellU Peptydy służą tak istotnej kwestii jak przywrócenie zaburzonej homeostazy. Uaktywniają tylko te szlaki metaboliczne, które są w danej chwili niezbędne, co zapewnia właśnie ich naturalna specyfika. Dlatego tak korzystne dla utrzymania zdrowia i dobrej kondycji jest stałe, profilaktyczne przyjmowanie preparatów z aktywnymi biologicznie, naturalnymi peptydami w Biopeptide Complex.

Peptydy – klucz do długowieczności

Andrzej Frydrychowski

Peptides are said to speed up the repair of cells and tissues and increase collagen production.

„They stimulate the activity of heat shock proteins, such as HSP70, thereby greatly speeding up the regeneration and repair of cells and tissues. This can be seen in the treatment of burns, frostbite, and wounds, and during recovery after procedures. As signaling peptides, they act on fibroblasts, increasing their collagen production—a factor that matters for the condition of all organs made of collagen protein: from the tips of the nails, through the skin, hair, gums, and eyeballs, to the bones and cartilage.”Pobudzają aktywność białek szoku termicznego, np. HSP70, przez co wybitnie przyspieszają regenerację i naprawę komórek oraz tkanek, co widoczne jest podczas leczenia poparzeń, odmrożeń, ran, w trakcie rekonwalescencji po zabiegach. Jako peptydy sygnałowe działają na fibroblasty, zwiększając ich produkcję kolagenu – co istotne jest dla stanu wszystkich organów, które zbudowane są z białka kolagenowego: od czubków paznokci, poprzez skórę, włosy, dziąsła, gałki oczne, na kościach i chrząstkach kończąc.

Peptydy – klucz do długowieczności

Andrzej Frydrychowski

Andrzej Frydrychowski describes peptides as substances of great importance to lifespan and quality of life.

„Experts say it is possible to live longer while remaining fit and healthy. Alongside a few small changes we should make to our lifestyles, peptides were named as substances of considerable importance to lifespan and quality of life.”Zdaniem specjalistów możliwe jest wydłużenie długości życia przy jednoczesnym zachowaniu dobrej formy i zdrowia. Prócz kilku niewielkich zmian, jakie powinniśmy wprowadzić w naszym trybie życia, jako substancje o niebagatelnym znaczeniu dla długości i jakości życia wymieniono peptydy.

Peptydy – klucz do długowieczności

Research from PubMed · Europe PMC

We selected 3 studies with the best, positive results. This is a selection, not a full review of all research.

Total number of studies on this topic in PubMed: 6 140.

Turtle peptides extended lifespan and improved several health indicators in fruit flies.

Aim of the study: In traditional Chinese medicine, soft-shelled turtle protein and peptides serve as a nutraceutical for prolonging the lifespan. However, their effects on anti-aging have not been clarified scientifically in vivo.

Results: Herein, STP supplementation prolonged the mean lifespan by 20.23% and 9.04% in males and females, respectively, delaying the aging accompanied by climbing ability decline, enhanced gut barrier integrity, and improved anti-oxidation, starvation, and heat stress abilities, while it did not change the daily food intake. Mechanistically, STP enhanced autophagy and decreased oxidative stress by downregulating the target of rapamycin (TOR) signaling pathway. In addition, 95.18% of peptides from the identified sequences in STP could exert potential inhibitory effects on TOR through hydrogen bonds, van der Walls, hydrophobic interactions, and electrostatic interactions. The current study could provide a theoretical basis for the full exploitation of soft-shelled turtle aging prevention.

Soft-Shelled Turtle Peptides Extend Lifespan and Healthspan in Drosophila. · Nutrients 2022

Money for the studygovernment, public institutions · Agricultural and social development program of Yuyao, Ningbo Science and Technology Innovation 2025 Major Special Project

Do the authors have ties to companies?no — the authors say so

Did a manufacturer help with the study?NO

Type of studyanimal study

“Not stated” does not mean nobody paid — the database does not always record it.

Peptides from millet bran extended the lifespan of nematodes and increased their antioxidant enzyme activity.

Aim of the study: Millet bran as a by-product of millet grain processing remains a reservoir of active substances. In this study, functional millet bran peptides (MBPE) were obtained from bran proteins after alcalase hydrolysis and ultrafiltration.

Results: elegans, MBPE at 12.5 µg/mL significantly prolonged the lifespan by reducing lipid oxidation, oxidative stress, and lipofuscin levels. Furthermore, MBPE increased the activities of the antioxidant enzymes. Genetic analyses showed that MBPE-mediated longevity was due to a significant increase in the expression of daf-16 and skn-1, which are also involved in xenobiotic and oxidative stress responses. In conclusion, this study found that MBPE had antioxidant and life-prolonging effects, which are important for the development and utilization of millet bran proteins as resources of active ingredients.

Antioxidant Peptides Derived from Millet Bran Promote Longevity and Stress Resistance in Caenorhabditis elegans. · Plant Foods Hum Nutr 2023

Money for the studygovernment, public institutions · Shanxi Scholarship Council of China, Basic Research Program of Shanxi Province, Xinghuacun College of Shanxi University

Do the authors have ties to companies?not stated

Did a manufacturer help with the study?unknown

Type of studyanimal study

“Not stated” does not mean nobody paid — the database does not always record it.

In nematodes, egg-derived peptide supplementation extended lifespan and improved several measures of fitness in old age.

Aim of the study: Given the increasing focus on natural interventions for healthy aging, this research evaluates the longevity-promoting potential of egg-derived peptides (EPs) extracted from American shad (Alosa sapidissima). Using Caenorhabditis elegans as the experimental model, researchers found that 0.15 mg/mL EP supplementation extended lifespan by a remarkable 33.33%.

Results: Crucially, EP upregulated genes responsible for unsaturated fatty acid biosynthesis (fat-7 and elo-4) to optimize cell membrane fluidity. Conversely, it downregulated genes linked to fatty acid β-oxidation (acs-2, acox-1.5, ech-9, hacd-1) and endogenous stress responses (sod-3, hsp-16.1, hsf-1). Validated via qRT-PCR, these shifts indicate that EP extends lifespan by fundamentally remodeling lipid metabolism and maintaining redox homeostasis. Ultimately, these findings highlight EP as a highly promising functional food ingredient for promoting healthy aging.

Egg Peptides From American Shad Extend Lifespan and Healthspan in Caenorhabditis elegans via Lipid Metabolism Remodeling and Antioxidant Defense. · Chem Biodivers 2026

Money for the studycompany or manufacturer · Suzhou Health-originated Bio-technology Co., Ltd.

Do the authors have ties to companies?no — the authors say so

Did a manufacturer help with the study?YES

Type of studyanimal study

“Not stated” does not mean nobody paid — the database does not always record it.

Pisaczek does not judge who is right. It shows what was written and where to read it. Every sentence above has its source.