DiseasesHeartburn and stomach tablets — do medicines for excess stomach acid cause harm after years of use?
- M. S. Sater i H. A. Giha — Toll of Chronic Metabolic Acidosis at Molecular, Cellular, and Systemic Levels: A Conceptual Framework to Revisit Type 2 Diabetes (T2D) Pathophysiology
- Henryk Różański — Zaburzenia gospodarki magnezowej.
- Prof. Klaus F. Kopp — The Bicarbonate-Deficiency-Syndrome (BDS): Professor Dr. med. Klaus F. Kopp
M. S. Sater and H. A. Giha indicate that long-term use of proton pump inhibitors is associated with low magnesium and vitamin B12 levels, as well as a higher risk of C. difficile infection.
- It may also accelerate the progression of chronic kidney disease.
- Henryk Różański states that agents that neutralize gastric juice impair magnesium absorption.
- Prof. Klaus F. Kopp warns that sodium bicarbonate may cause gas, belching, heartburn and sometimes diarrhoea; he recommends caution in advanced kidney failure or during dialysis.
What the authors write
M. S. Sater i H. A. Giha
Long-term use of proton pump inhibitors is associated with low magnesium levels, vitamin B12 deficiency, a higher risk of C. difficile infection, and possibly faster progression of chronic kidney disease.
„Third, chronic proton pump inhibitor use is associated with hypomagnesaemia [217], vitamin B12 deficiency [218], elevated risk of Clostridioides difficile infection [219], and potential acceleration of chronic kidney disease progression [220]. All of the above are of disproportionate relevance to T2D patients and must be weighed against any putative metabolic benefit.”Third, chronic proton pump inhibitor use is associated with hypomagnesaemia [217], vitamin B12 deficiency [218], elevated risk of Clostridioides difficile infection [219], and potential acceleration of chronic kidney disease progression [220]. All of the above are of disproportionate relevance to T2D patients and must be weighed against any putative metabolic benefit.
Henryk Różański
Agents that neutralize gastric juice impair magnesium absorption.
„tetracycline). If calcium preparations are taken at the same time, magnesium should be consumed at a different time of day. Agents that neutralize gastric juice, cellulose preparations, fibre, medicinal charcoal, strong alcohols (e.g. vodka, cognac) impair magnesium absorption.”tetracykliną). Jeżeli równocześnie zażywamy preparaty wapnia – spożyć magnez w innym czasie dnia. Środki zobojętniające sok żołądkowy, preparaty celulozy, błonnika, węgiel leczniczy, alkohole mocne (np. wódki, koniak) – upośledzają przyswajanie magnezu.
Prof. Klaus F. Kopp
Taking sodium bicarbonate may cause gas, belching, heartburn and sometimes diarrhoea; it should be used with caution in advanced kidney failure or during dialysis.
„The oral intake of Bicarbonate may lead to the formation of carbon-dioxide (CO2) gas and foam in the stomach, with eructations and heartburn and sometimes to diarrhoea. In patients with far advanced renal failure or in patients on dialysis sodium bicarbonate should be administered with caution and should be controlled by the patient using the measurement of urine-pH.”The oral intake of Bicarbonate may lead to the formation of carbon-dioxide (CO2) gas and foam in the stomach, with eructations and heartburn and sometimes to diarrhoea. In patients with far advanced renal failure or in patients on dialysis sodium bicarbonate should be administered with caution and should be controlled by the patient using the measurement of urine-pH.
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