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Vaccines

HPV vaccine — why are there concerns about girls’ fertility?

Sources: 7 · Article: 10 029 characters

The STOP NOP Association says the plaintiffs linked the HPV vaccine to premature ovarian insufficiency leading to infertility.

  • The concerns mentioned also included premature menopause and female infertility.
  • The Association questions the quality of some of the 225 studies and says their observational nature and lack of randomization make it difficult to assess rare complications.

What the authors write

Stowarzyszenie STOP NOP

The plaintiffs accused the HPV vaccine of causing premature ovarian insufficiency leading to infertility.

„The plaintiffs accused the vaccine of causing, among other things, premature ovarian insufficiency leading to infertility, POTS, autoimmune disorders, and other serious conditions. Merck, the manufacturer of the HPV vaccine, had the opportunity to prove in court that its product was safe, but preferred to settle without any finding of liability and pay money Gardasil Injury Settlement Several safety signals were recently detected in the U.S. Vaccine Adverse Event Reporting System (VAERS), confirming the accounts of Danish girls and U.S. lawsuits.”Powodowie zarzucali szczepionce m.in. przedwczesną niewydolność jajników prowadzącą do bezpłodności, POTS, zaburzenia autoimmunologiczne i inne poważne. Merck, producent szczepionki przeciw HPV, miał okazję udowodnić przed sądem bezpieczeństwo swojego produktu, ale wolał pójść na ugodę bez orzekania o winie i wypłacić pieniądze Gardasil Injury Settlement W amerykańskim systemie zgłaszania niepożądanych zdarzeń po szczepieniach (VAERS) ostatnio wykryto kilka sygnałów bezpieczeństwa, które potwierdzają historie duńskich dziewczyn i pozwów amerykańskich.
Lekarze ostrzegają! Szczepionka HPV – Ogólnopolskie Stowarzyszenie Wiedzy o Szczepieniach "STOP NOP"
Stowarzyszenie STOP NOP

The concerns mentioned included premature menopause and female infertility.

„-Premature menopause and female infertility”-Przedwczesna menopauza i niepłodność żeńska
Lekarze ostrzegają! Szczepionka HPV – Ogólnopolskie Stowarzyszenie Wiedzy o Szczepieniach "STOP NOP"
Stowarzyszenie STOP NOP

A review of 225 studies found no association between HPV vaccination and an increased risk of premature ovarian insufficiency or infertility.

„https://pmc.ncbi.nlm.nih.gov/articles/PMC12640735/ – 225 studies, more than 132 million people: HPV vaccination was not associated with an increased risk of postural orthostatic tachycardia syndrome (POTS), chronic fatigue syndrome / ME, paralysis, complex regional pain syndrome (CRPS), premature ovarian insufficiency, or infertility.”https://pmc.ncbi.nlm.nih.gov/articles/PMC12640735/ – 225 badań, ponad 132 mln osób: szczepienie HPV nie było związane ze zwiększonym ryzykiem zespołu posturalnej tachykardii ortostatycznej (POTS), zespołu przewlekłego zmęczenia / ME, porażenia, kompleksowego zespołu bólu regionalnego (CRPS), przedwczesnej niewydolności jajników, niepłodności.
Lekarze ostrzegają! Szczepionka HPV – Ogólnopolskie Stowarzyszenie Wiedzy o Szczepieniach "STOP NOP"
Stowarzyszenie STOP NOP

The STOP NOP Association questions the quality of some of these studies and says their observational nature and lack of randomization make it difficult to assess rare complications.

„A significant proportion of these studies have conflicts of interest and are based on low-quality data. The main limitation of this review is the lack of randomization, the observational nature of the studies, and the low quality and completeness of clinical diagnoses. These studies are poor at detecting serious, rare complications because they measure hospital codes for selected clinical conditions in non-equivalent groups (without randomization), rather than actual disease across the entire population.”Istotna cześć tych badań ma konflikty interesów i opiera się na niskiej jakości danych. W tym przeglądzie wąskim gardłem jest brak randomizacji, obserwacyjny charakter badań oraz niska jakość i kompletność rozpoznań klinicznych. Te badania są słabe w wykrywaniu poważnych, rzadszych powikłań, bo mierzą kody szpitalne wybranych stanów klinicznych w grupach nierównoważnych (brak randomizacji), a nie rzeczywistą chorobę w całej populacji.
Lekarze ostrzegają! Szczepionka HPV – Ogólnopolskie Stowarzyszenie Wiedzy o Szczepieniach "STOP NOP"

Research from PubMed · Europe PMC

We selected 3 studies with the best, positive results. This is a selection, not a full review of all research.

Total number of studies on this topic in PubMed: 68.

A review of studies from West Africa found that safety concerns, including concerns about the vaccine’s effect on fertility, are among the reasons for vaccine hesitancy.

Aim of the study: Human papillomavirus (HPV) infections are mostly sexually transmitted and cause the greatest share of infection-associated cancers. Each year more than half a million women are diagnosed with cervical cancer and the mortality rate in West Africa is over ten times higher than that of Northern Europe.

Results: Several studies also mentioned fertility and promiscuity concerns. Despite over half of West African countries introducing an HPV vaccine pilot project, there is a scarcity of literature on HPV vaccine acceptance in the region. It is important to understand how cultural and gender dynamics in different settings can influence peoples' vaccination decisions. This can be done through in-depth local ethnographies, taking the views of all community members and influencers into account, and complemented by in-depth individual interviews and focus groups.

HPV vaccine acceptance in West Africa: A systematic literature review. · Vaccine 2021
Money for the studynot stated
Do the authors have ties to companies?not stated
Did a manufacturer help with the study?unknown
Type of studyreview of many studies

“Not stated” does not mean nobody paid — the database does not always record it.

A review of studies from the Asia-Pacific region noted that some women were concerned about the vaccine’s effect on fertility.

Aim of the study: To inform human papillomavirus (HPV) vaccination programs in the Asian Pacific region by elucidating factors associated with women's intent to receive the vaccine.

Results: Of the 60 studies yielded by the search, 18 met inclusion criteria (13 quantitative, 5 qualitative). All quantitative studies were cross-sectional and all but one assessed vaccination intent rather than actual uptake. Awareness and knowledge of HPV, HPV-related conditions, and HPV vaccination varied greatly among studies. Several studies found women's perceived susceptibility to HPV-related conditions to be positively associated with HPV vaccine intent. Across seven quantitative studies in five countries, women's concerns about the vaccine's safety and efficacy were associated with their intent to be vaccinated. Social consequences and support from social referents were also influential in many women's decisions. Qualitative research also revealed that many women were concerned that the vaccine would affect fertility. HPV vaccine campaigns should address gaps in knowledge regarding HPV, genital warts, and cervical cancer, and should attend to concerns about vaccine safety and efficacy.

HPV vaccine acceptance among women in the Asian Pacific: a systematic review of the literature. · Asian Pac J Cancer Prev 2010
Money for the studynot stated
Do the authors have ties to companies?not stated
Did a manufacturer help with the study?unknown
Type of studyreview of many studies

“Not stated” does not mean nobody paid — the database does not always record it.

The study found a lower proportion of births at younger ages among vaccinated women, but the authors noted that this may have resulted from counseling and later family planning, rather than fertility problems.

Aim of the study: Prophylactic HPV vaccines are effective against cervical cancer and its precursors, but data on their impact on fertility and pregnancy are limited. This registry-based study examined the association between HPV vaccination and childbirth rates.

Results: At the age of 28, the cumulative proportion of all childbirths among HPV-vaccinated and screened cohorts was 2277 (36.7%), among HBV-vaccinated 781 (46.9%) and among unvaccinated reference cohorts 8997 (46.2%). Childbirth rates per 10,000 person years were 306 (95% CI 294-319), 390 (95% CI 364-419) and 385 (95% CI 377-393), respectively. HPV-vaccinated and screened women had lower childbirth rates compared to unvaccinated women at young age, possibly due to sexual counseling that HPV-vaccinated participants got in an overlapping cervical screening trial conducted between ages 22 and 28. This may have postponed their family planning to later ages.

Human papillomavirus vaccinations' association to childbirth rates. · Hum Vaccin Immunother 2026
Money for the studygovernment, public institutions · Research Council of Finland, Finnish Cancer Foundation, Sigrid Juselius Foundation
Do the authors have ties to companies?yes — the authors reported it
Did a manufacturer help with the study?YES
Type of studyobservation of people

“Not stated” does not mean nobody paid — the database does not always record it.

Perspectives and opinion materials

The content below presents the authors’ opinions, interpretations and hypotheses. It is not treated as equal to scientific studies and systematic reviews.

Orthomolecular Medicine News Service Opinion material
„Three of eleven control variables that were investigated (i.e., child poverty rate, pertussis vaccination rate, and teenage fertility rate) were statistically significant. None of these variables lowered the correlation below 0.62, thus robustly confirming the original findings [5].”Three of eleven control variables that were investigated (i.e., child poverty rate, pertussis vaccination rate, and teenage fertility rate) were statistically significant. None of these variables lowered the correlation below 0.62, thus robustly confirming the original findings [5].
Positive Correlation between the Number of Vaccine Doses and Infant Mortality
Orthomolecular Medicine News Service Opinion material
„Health Culture Magazine for January, 1936 said, "The fertility food factor is now called vitamin E. The expectant mother requires vitamin E to insure the carriage of her charge to a complete and natural term. If her diet is deficient in vitamin E, the woman is very apt to abort. It is more difficult to insure a liberal vitamin E supply in the daily average diet than to insure an adequate supply of any other known vitamin." "As early as 1931, Vogt-Moller of Denmark successfully treated habitual abortion in human females with wheat germ oil vitamin E. By 1939 he had treated several hundred women with a success rate of about 80%.”Health Culture Magazine for January, 1936 said, "The fertility food factor is now called vitamin E. The expectant mother requires vitamin E to insure the carriage of her charge to a complete and natural term. If her diet is deficient in vitamin E, the woman is very apt to abort. It is more difficult to insure a liberal vitamin E supply in the daily average diet than to insure an adequate supply of any other known vitamin." "As early as 1931, Vogt-Moller of Denmark successfully treated habitual abortion in human females with wheat germ oil vitamin E. By 1939 he had treated several hundred women with a success rate of about 80%.
Not Taking Supplements Causes Miscarriage, Birthing Problems, Infant Mortality
Orthomolecular Medicine News Service Opinion material
„"Herd immunity" is achieved when one generation of livestock or humans fully experiences and resolves infectious disease conditions, gains the immune-system information, and then passes that information to the next generation. Part of this immune system information is conveyed through the herd microbiome. When orthomolecular methods are employed to treat any and all disease symptoms on a farm, the farm immune system fully experiences the disease, without chemical disruption of the body or the microbiome. The immune system and microbiome are tuned through the complete disease process, while the individual experiences minimal suffering. Dr.”"Herd immunity" is achieved when one generation of livestock or humans fully experiences and resolves infectious disease conditions, gains the immune-system information, and then passes that information to the next generation. Part of this immune system information is conveyed through the herd microbiome. When orthomolecular methods are employed to treat any and all disease symptoms on a farm, the farm immune system fully experiences the disease, without chemical disruption of the body or the microbiome. The immune system and microbiome are tuned through the complete disease process, while the individual experiences minimal suffering. Dr.
Orthomolecular plus Microbiome Science: Restoring the Immune System of a Farm Community

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