Herb-Robert — an inconspicuous plant for diarrhea and bleeding?

Aim of the study: In this modern era, in which interest in natural compounds is gaining more ground, Geranium robertianum L. (Gr), a species with long use in traditional medicine, stands out for its promising potential in managing a multitude of health issues.

Results: and the searched phytocompound and biological effect. According to the literature the main phytochemical classes identified in different types of extracts include tannins, flavonoids, phenolic acids, and essential oils. The most important biological actions described in the literature are antioxidant, anti-inflammatory, antimicrobial, antiulcerative, neuroprotective, anti-cancer, and antidiabetic effects. However, knowledge about Gr is still relatively limited, requiring more detailed study regarding its pharmacological proprieties and the molecular mechanisms behind them.

Aim of the study: The paper presents a study of the associated effect of acyclovir and a plant extract from Calendula officinalis, Actium lappa and Geranium robertianum. We studied a number of 52 patients suffering of herpetic keratitis.

Results: The paper presents a study of the associated effect of acyclovir and a plant extract from Calendula officinalis, Actium lappa and Geranium robertianum. We studied a number of 52 patients suffering of herpetic keratitis. Better results in resolving complains and faster healing of ulceration were obtained using the associated treatment then the usual acyclovir treatment only.

Aim of the study: In search for effective prophylactic and possibly curative therapeutics against SARS-CoV-2, an historical-ethnopharmacological approach was used to select plants described in the Receptarium of Burkhard III von Hallwyl (RBH), a recipe text from 16th century Switzerland. Ten plant species were selected from the pre-established RBH database based on specific historical uses presumably linked with the treatment of viral infections.

Results: Of the ten plants tested, four displayed an antiviral activity ≥ 50% at 16.7 μg/ml with acceptable cell viability (> 75%): Artemisia vulgaris L. (aerial parts), Geranium robertianum L. (arial parts), Sambucus nigra L. (leaves) and Viola odorata L. (leaves). The crude extracts were partitioned in aqueous and organic pre-fractions and further analyzed. The ethyl acetate pre-fractions of G. robertianum, S. nigra, and V. odorata expressed significant antiviral activity of nearly 100% at 5.6 μg/ml (P < 0.05). The most potent inhibitory activity was observed for the ethyl acetate pre-fraction of the leaves of Viola odorata with 87% at 1.9 μg/ml (P < 0.0001). Alongside bioactivity testing, phytochemical fingerprints were made, with the aim to provide a preliminary characterization of the active crude extracts. An overview of published phytochemical and antiviral data on the four active plants reveals a fragmentary picture, especially when considering the plant parts investigated.

Aim of the study: Background: Geranium robertianum L. (GR) is a perennial herbaceous plant that belongs to the Geraniaceae family, widely distributed across temperate regions of Europe, Asia, North Africa, and America.

Results: Recent studies have confirmed that these constituents are responsible for the plant's therapeutic potential in oral medicine. These compounds possess a variety of effects, from antibacterial and anti-inflammatory properties to antifungal and antiviral activities, as well as antioxidant, wound-healing, and anticancer benefits relevant to dental medicine. Conclusions: Despite its long-standing traditional use, GR remains largely underexplored in the context of oral health. This gap in the literature highlights GR as a promising phytotherapeutic candidate, calling for further in vitro and in vivo studies in order to investigate its efficacy and establish its mechanism of action in dental medicine.