Herbs and plantsLicorice for a cough — sweet root instead of syrup?
Sources: 9 · Article: 23 475 characters
Henryk Różański describes licorice as a remedy that soothes coughs and helps clear mucus from the respiratory tract.
- He gives a daily dose of 10–20 g of root, to make a decoction or infusion.
- He recommends short courses of up to a month, followed by a break.
- Long-term use of licorice may cause swelling and high blood pressure. The listed contraindications include pregnancy, breastfeeding, and kidney and liver failure, among others.
What the authors write
Henryk Różański
Licorice preparations have been described as soothing coughs and helping clear mucus from the respiratory tract.
„Licorice preparations were described as agents that dissolve mucus accumulated in the respiratory tract, soothe coughs, and regulate bowel movements. For 1 L of water, 10–15 g of chopped root was used and boiled to make a decoction. It was given for coughs, colds, and constipation.”Preparaty lukrecjowe były opisywane jako środek roztwarzający zalegające śluzy w drogach oddechowych, łagodzący kaszel i regulujący wypróżnienia. Na 1 l wody dawano 10-15 g korzenia rozdrobnionego i gotowano (odwar). Podawano przy kaszlu, przeziębieniu, zaparciu.
Henryk Różański
In the 19th century, a decoction made from 10–15 g of chopped root per liter of water was given for coughs and colds.
„For 1 L of water, 10–15 g of chopped root was used and boiled to make a decoction. It was given for coughs, colds, and constipation. Children were given compresses of the decoction on their stomachs to stimulate defecation (passing stool). In England, licorice extract was an ingredient in beer.”Na 1 l wody dawano 10-15 g korzenia rozdrobnionego i gotowano (odwar). Podawano przy kaszlu, przeziębieniu, zaparciu. Dzieciom czyniono okłady z odwaru na brzuszek dla pobudzenia defekacji (wydalenia kału). W Anglii wyciąg z lukrecji był składnikiem piwa.
Henryk Różański
Licorice preparations have been described as soothing coughs and helping clear mucus from the respiratory tract.
„Licorice preparations were described as agents that dissolve mucus accumulated in the respiratory tract, soothe coughs, and regulate bowel movements. For 1 L of water, 10–15 g of chopped root was used and boiled to make a decoction. It was given for coughs, colds, and constipation.”Preparaty lukrecjowe były opisywane jako środek roztwarzający zalegające śluzy w drogach oddechowych, łagodzący kaszel i regulujący wypróżnienia. Na 1 l wody dawano 10-15 g korzenia rozdrobnionego i gotowano (odwar). Podawano przy kaszlu, przeziębieniu, zaparciu.
Henryk Różański
In the 19th century, a decoction made from 10–15 g of chopped root per liter of water was given for coughs and colds.
„For 1 L of water, 10–15 g of chopped root was used and boiled to make a decoction. It was given for coughs, colds, and constipation. Children were given compresses of the decoction on their stomachs to stimulate defecation (passing stool). In England, licorice extract was an ingredient in beer.”Na 1 l wody dawano 10-15 g korzenia rozdrobnionego i gotowano (odwar). Podawano przy kaszlu, przeziębieniu, zaparciu. Dzieciom czyniono okłady z odwaru na brzuszek dla pobudzenia defekacji (wydalenia kału). W Anglii wyciąg z lukrecji był składnikiem piwa.
Henryk Różański
Cough, hoarseness, and bronchitis were listed among the uses of licorice.
„Uses: joint inflammation, cough, hoarseness, bronchitis, and pneumonia;”Wskazania: stany zapalne stawów, kaszel, chrypka, zapalenie oskrzeli i płuc;
Henryk Różański
Cough, hoarseness, and bronchitis were listed among the uses of licorice.
„Uses: joint inflammation, cough, hoarseness, bronchitis, and pneumonia;”Wskazania: stany zapalne stawów, kaszel, chrypka, zapalenie oskrzeli i płuc;
Henryk Różański
A dose of 10–20 g of root per day was given, preferably to prepare a decoction or infusion.
„Daily root dose: 10–20 g, preferably for making a decoction or infusion; tincture, extract, and dry extract may also be used as appropriate (see below). For external use, it may be used to wash or apply compresses to the skin for discoloration, freckles and dryness, inflammation, psoriasis, eczema, lupus, wounds that are slow to heal, and burns.”Dawki korzenia w ciągu dnia: 10-20 g, najlepiej do przygotowania odwaru lub naparu; ponadto odpowiednio nalewka, ekstrakt i wyciąg suchy (patrz dalej). Zewnętrznie do przemywania i okładania skóry przy przebarwieniach, piegach i suchości, stanach zapalnych, łuszczycy, wypryskach, toczniu, trudno gojących się ranach i oparzeniach.
Henryk Różański
The decoction should be boiled for 5–15 minutes, and the infusion steeped for 30–40 minutes; the recommended amount was one glass, 2–4 times a day.
„Boil the decoction for 5–15 minutes or steep the infusion for 30–40 minutes, then strain. Drink 1 glass of the infusion or decoction 2–4 times a day; for catarrh of the digestive or respiratory tract, take small amounts often. For children, it can be brewed in milk with honey or raspberry juice.”Odwar trzeba gotować 5-15 minut, napar parzyć 30-40 minut; przecedzić. Pić po 1 szklance naparu/odwaru 2-4 razy dziennie; w nieżytach układu pokarmowego i oddechowego – małe dawki, ale często. Dla dzieci można parzyć w mleku z miodem lub sokiem malinowym.
Henryk Różański
Contraindications to long-term use included pregnancy, breastfeeding, high blood pressure, and kidney and liver failure.
„Contraindications to long-term use: hyperaldosteronism, pregnancy, breastfeeding, high blood pressure, kidney and liver failure, and hypokalemia. It can be used safely in short courses lasting 1–4 weeks.
Licorice increases the effects of buckthorn, senna, alder buckthorn, spindle tree, foxglove, sea squill, strophanthus, pheasant's eye, and lily of the valley.”Przeciwwskazania do długotrwałego stosowania: hiperaldosteronizm, ciąża, laktacja, nadciśnienie, niewydolność nerek i wątroby, hipokaliemia. Może być bezpiecznie stosowana w kuracjach krótkotrwałych, 1-4 tygodniowych.
Lukrecja nasila działanie kruszyny, senesu, szakłaku, trzmieliny, naparstnicy, cebuli morskiej, strofantusa, miłka i konwalii.
Henryk Różański
Licorice was described as suitable for short courses lasting 1–4 weeks.
„It can be used safely in short courses lasting 1–4 weeks.
Licorice increases the effects of buckthorn, senna, alder buckthorn, spindle tree, foxglove, sea squill, strophanthus, pheasant's eye, and lily of the valley. It has a synergistic effect with mullein, primrose, anise, opium, codeine, and greater celandine.”Może być bezpiecznie stosowana w kuracjach krótkotrwałych, 1-4 tygodniowych.
Lukrecja nasila działanie kruszyny, senesu, szakłaku, trzmieliny, naparstnicy, cebuli morskiej, strofantusa, miłka i konwalii. Wykazuje synergizm z dziewanną, pierwiosnkiem, anyżem, opium, kodeiną i glistnikiem.
Henryk Różański
Licorice combined with codeine, opium, or certain other ingredients is said to suppress the cough center more effectively.
„Codeine, opium, greater celandine, California poppy, etc., combined with licorice, suppress the cough center more effectively.
A review of selected pharmacopoeias:
The 1758 Pharmacopoea Parisiensis (Paris Pharmacopoeia) listed it under the names Glycyrrhisa, feu Liquritia; La Reglise; Glycyrrhisa silliquosa, vel Germanica (root, pills, pastilles, powder, syrup, decoction, juice).”Kodeina, opium, glistnik, maczek kalifornijski itp. w połączeniu z lukrecją lepiej hamują ośrodek kaszlu.
Przegląd wybranych farmakopei:
Pharmacopoea Parisiensis (Farmakopea Paryska) z 1758 r: pod nazwą Glycyrrhisa, feu Liquritia; La Reglise; Glycyrrhisa silliquosa, vel Germanica (korzeń, pigułki, powidełka, proszek, syrop, odwar, sok).
Henryk Różański
An old list mentions licorice syrup and decoction as forms of the plant.
„combined with licorice, suppress the cough center more effectively.
A review of selected pharmacopoeias:
The 1758 Pharmacopoea Parisiensis (Paris Pharmacopoeia) listed it under the names Glycyrrhisa, feu Liquritia; La Reglise; Glycyrrhisa silliquosa, vel Germanica (root, pills, pastilles, powder, syrup, decoction, juice).”w połączeniu z lukrecją lepiej hamują ośrodek kaszlu.
Przegląd wybranych farmakopei:
Pharmacopoea Parisiensis (Farmakopea Paryska) z 1758 r: pod nazwą Glycyrrhisa, feu Liquritia; La Reglise; Glycyrrhisa silliquosa, vel Germanica (korzeń, pigułki, powidełka, proszek, syrop, odwar, sok).
Henryk Różański
The same daily root dose was given: 10–20 g for a decoction or infusion.
„Daily root dose: 10–20 g, preferably for making a decoction or infusion; tincture, extract, and dry extract may also be used as appropriate (see below). For external use, it may be used to wash or apply compresses to the skin for discoloration, freckles and dryness, inflammation, psoriasis, eczema, lupus, wounds that are slow to heal, and burns.”Dawki korzenia w ciągu dnia: 10-20 g, najlepiej do przygotowania odwaru lub naparu; ponadto odpowiednio nalewka, ekstrakt i wyciąg suchy (patrz dalej). Zewnętrznie do przemywania i okładania skóry przy przebarwieniach, piegach i suchości, stanach zapalnych, łuszczycy, wypryskach, toczniu, trudno gojących się ranach i oparzeniach.
Henryk Różański
The decoction should be boiled for 5–15 minutes, and the infusion steeped for 30–40 minutes; the recommended amount was one glass, 2–4 times a day.
„Boil the decoction for 5–15 minutes or steep the infusion for 30–40 minutes, then strain. Drink 1 glass of the infusion or decoction 2–4 times a day; for catarrh of the digestive or respiratory tract, take small amounts often. For children, it can be brewed in milk with honey or raspberry juice.”Odwar trzeba gotować 5-15 minut, napar parzyć 30-40 minut; przecedzić. Pić po 1 szklance naparu/odwaru 2-4 razy dziennie; w nieżytach układu pokarmowego i oddechowego – małe dawki, ale często. Dla dzieci można parzyć w mleku z miodem lub sokiem malinowym.
Henryk Różański
Contraindications to long-term use included pregnancy, breastfeeding, high blood pressure, and kidney and liver failure.
„Contraindications to long-term use: hyperaldosteronism, pregnancy, breastfeeding, high blood pressure, kidney and liver failure, and hypokalemia. It can be used safely in short courses lasting 1–4 weeks.
Licorice increases the effects of buckthorn, senna, alder buckthorn, spindle tree, foxglove, sea squill, strophanthus, pheasant's eye, and lily of the valley.”Przeciwwskazania do długotrwałego stosowania: hiperaldosteronizm, ciąża, laktacja, nadciśnienie, niewydolność nerek i wątroby, hipokaliemia. Może być bezpiecznie stosowana w kuracjach krótkotrwałych, 1-4 tygodniowych.
Lukrecja nasila działanie kruszyny, senesu, szakłaku, trzmieliny, naparstnicy, cebuli morskiej, strofantusa, miłka i konwalii.
Henryk Różański
Licorice was described as suitable for short courses lasting 1–4 weeks.
„It can be used safely in short courses lasting 1–4 weeks.
Licorice increases the effects of buckthorn, senna, alder buckthorn, spindle tree, foxglove, sea squill, strophanthus, pheasant's eye, and lily of the valley. It has a synergistic effect with mullein, primrose, anise, opium, codeine, and greater celandine.”Może być bezpiecznie stosowana w kuracjach krótkotrwałych, 1-4 tygodniowych.
Lukrecja nasila działanie kruszyny, senesu, szakłaku, trzmieliny, naparstnicy, cebuli morskiej, strofantusa, miłka i konwalii. Wykazuje synergizm z dziewanną, pierwiosnkiem, anyżem, opium, kodeiną i glistnikiem.
Henryk Różański
Licorice combined with codeine, opium, or certain other ingredients is said to suppress the cough center more effectively.
„Codeine, opium, greater celandine, California poppy, etc., combined with licorice, suppress the cough center more effectively.
A review of selected pharmacopoeias:
The 1758 Pharmacopoea Parisiensis (Paris Pharmacopoeia) listed it under the names Glycyrrhisa, feu Liquritia; La Reglise; Glycyrrhisa silliquosa, vel Germanica (root, pills, pastilles, powder, syrup, decoction, juice).”Kodeina, opium, glistnik, maczek kalifornijski itp. w połączeniu z lukrecją lepiej hamują ośrodek kaszlu.
Przegląd wybranych farmakopei:
Pharmacopoea Parisiensis (Farmakopea Paryska) z 1758 r: pod nazwą Glycyrrhisa, feu Liquritia; La Reglise; Glycyrrhisa silliquosa, vel Germanica (korzeń, pigułki, powidełka, proszek, syrop, odwar, sok).
Henryk Różański
An old list mentions licorice syrup and decoction as forms of the plant.
„combined with licorice, suppress the cough center more effectively.
A review of selected pharmacopoeias:
The 1758 Pharmacopoea Parisiensis (Paris Pharmacopoeia) listed it under the names Glycyrrhisa, feu Liquritia; La Reglise; Glycyrrhisa silliquosa, vel Germanica (root, pills, pastilles, powder, syrup, decoction, juice).”w połączeniu z lukrecją lepiej hamują ośrodek kaszlu.
Przegląd wybranych farmakopei:
Pharmacopoea Parisiensis (Farmakopea Paryska) z 1758 r: pod nazwą Glycyrrhisa, feu Liquritia; La Reglise; Glycyrrhisa silliquosa, vel Germanica (korzeń, pigułki, powidełka, proszek, syrop, odwar, sok).
Henryk Różański
Long-term use of licorice may cause the body to retain salt, leading to swelling and high blood pressure.
„Therefore, it must not be used in hypernatremia (excess sodium) or hypokalemia (low potassium)./ Long-term use of licorice preparations causes sodium chloride to be retained in the body and increases the water content of tissues, resulting in swelling and high blood pressure.”Dlatego też nie może być stosowany przy hipernatremii (nadmiarze sodu) i hipokaliemii (niedoborze potasu)./ Długotrwale stosowane preparaty lukrecji zatrzymują chlorek sodu w ustroju i zwiększają nawodnienie tkanek co przejawia się obrzękami i nadciśnieniem.
Henryk Różański
Licorice was recommended for short-term use, for up to a month, followed by a break.
„Therefore, it must not be used in hypernatremia (excess sodium) or hypokalemia (low potassium)./ Long-term use of licorice preparations causes sodium chloride to be retained in the body and increases the water content of tissues, resulting in swelling and high blood pressure. Licorice should be used for a short time, for up to a month, followed by a break from taking it.”Dlatego też nie może być stosowany przy hipernatremii (nadmiarze sodu) i hipokaliemii (niedoborze potasu)./ Długotrwale stosowane preparaty lukrecji zatrzymują chlorek sodu w ustroju i zwiększają nawodnienie tkanek co przejawia się obrzękami i nadciśnieniem. Lukrecja powinna być stosowana krótkotrwale, do miesiąca, potem należy uczynić przerwę w jej podawaniu (przyjmowaniu).
Henryk Różański
Long-term use of licorice may cause the body to retain salt, leading to swelling and high blood pressure.
„Therefore, it must not be used in hypernatremia (excess sodium) or hypokalemia (low potassium)./ Long-term use of licorice preparations causes sodium chloride to be retained in the body and increases the water content of tissues, resulting in swelling and high blood pressure.”Dlatego też nie może być stosowany przy hipernatremii (nadmiarze sodu) i hipokaliemii (niedoborze potasu)./ Długotrwale stosowane preparaty lukrecji zatrzymują chlorek sodu w ustroju i zwiększają nawodnienie tkanek co przejawia się obrzękami i nadciśnieniem.
Henryk Różański
Licorice was recommended for short-term use, for up to a month, followed by a break.
„Therefore, it must not be used in hypernatremia (excess sodium) or hypokalemia (low potassium)./ Long-term use of licorice preparations causes sodium chloride to be retained in the body and increases the water content of tissues, resulting in swelling and high blood pressure. Licorice should be used for a short time, for up to a month, followed by a break from taking it.”Dlatego też nie może być stosowany przy hipernatremii (nadmiarze sodu) i hipokaliemii (niedoborze potasu)./ Długotrwale stosowane preparaty lukrecji zatrzymują chlorek sodu w ustroju i zwiększają nawodnienie tkanek co przejawia się obrzękami i nadciśnieniem. Lukrecja powinna być stosowana krótkotrwale, do miesiąca, potem należy uczynić przerwę w jej podawaniu (przyjmowaniu).
Henryk Różański
A recipe was given for an expectorant and cough-relief mixture containing licorice root; the infusion should be drunk in small amounts.
„Rp. Species pectorales Dr. Hennigs (expectorant and cough-relief herbal mixture): Florum Tiliae (linden flowers) 5.0; Fructus anisi (anise fruit) 5.0; Radicis Senegae 5.0 (may be replaced with primrose flowers, sweet violet root or herb, asarabacca rhizome, or soapwort root); Rhizom. Iridis flor. 10.0 (iris rhizome); Radicis Liquiritiae 15.0; Stipit. Dulcamarae 15.0 (shoot tips of bittersweet nightshade); Fruct. Coriandri 20.0 (chopped coriander fruit); Carragen 25.0 (may be replaced with agar, kelp, or bladderwrack). Use 1 teaspoon per 250 ml of boiling water, bring to a boil, and leave to stand. Drink in small amounts.”Rp. Species pectorales Dr. Hennigs (ziółka wykrztuśne i przeciwkaszlowe) Florum Tiliae (kwiat lipy) 5,0 Fructus anisi (owoc anyżu) 5,0 Radicis Senegae 5,0 (można zastąpić kwiatem pierwiosnka, korzeniem lub zielem fiołka wonnego, kłączem kopytnika lub korzeniem mydlnicy) Rhizom. Iridis flor. 10,0 (kłącze kosaćca, irysa) Radicis Liquiritiae 15,0 Stipit. Dulcamarae 15,0 (wierzchołki pędów psianki słodkogórz) Fruct. Coriandri 20,0 (owoc kolendry rozdrobniony) Carragen 25,0 (można zastąpić agarem, listownicą lub morszczynem) 1 łyżeczka na 250 ml wrzącej wody, zagotować, odstawić. Pić małymi porcjami.
Henryk Różański
A recipe was given for an expectorant and cough-relief mixture containing licorice root; the infusion should be drunk in small amounts.
„Rp. Species pectorales Dr. Hennigs (expectorant and cough-relief herbal mixture): Florum Tiliae (linden flowers) 5.0; Fructus anisi (anise fruit) 5.0; Radicis Senegae 5.0 (may be replaced with primrose flowers, sweet violet root or herb, asarabacca rhizome, or soapwort root); Rhizom. Iridis flor. 10.0 (iris rhizome); Radicis Liquiritiae 15.0; Stipit. Dulcamarae 15.0 (shoot tips of bittersweet nightshade); Fruct. Coriandri 20.0 (chopped coriander fruit); Carragen 25.0 (may be replaced with agar, kelp, or bladderwrack). Use 1 teaspoon per 250 ml of boiling water, bring to a boil, and leave to stand. Drink in small amounts.”Rp. Species pectorales Dr. Hennigs (ziółka wykrztuśne i przeciwkaszlowe) Florum Tiliae (kwiat lipy) 5,0 Fructus anisi (owoc anyżu) 5,0 Radicis Senegae 5,0 (można zastąpić kwiatem pierwiosnka, korzeniem lub zielem fiołka wonnego, kłączem kopytnika lub korzeniem mydlnicy) Rhizom. Iridis flor. 10,0 (kłącze kosaćca, irysa) Radicis Liquiritiae 15,0 Stipit. Dulcamarae 15,0 (wierzchołki pędów psianki słodkogórz) Fruct. Coriandri 20,0 (owoc kolendry rozdrobniony) Carragen 25,0 (można zastąpić agarem, listownicą lub morszczynem) 1 łyżeczka na 250 ml wrzącej wody, zagotować, odstawić. Pić małymi porcjami.
Research from PubMed · Europe PMC
We selected 6 studies with the best, positive results. This is a selection, not a full review of all research.
Total number of studies on this topic in PubMed: 106.
In guinea pigs, two licorice compounds reduced the frequency of chemically induced coughs.
Aim of the study: Transient receptor potential vanilloid 1 (TRPV1) and ankyrin 1 (TRPA1) are two nociceptive TRP channel subtypes that play central roles in cough hypersensitivity. This study evaluated the antitussive efficacy of liquiritin apioside (LIQA) and liquiritin (LIQ), two major flavonoid glycosides from licorice, in acute chemically induced cough models, and investigated their modulations of TRPA1 and TRPV1.
Results: LIQA and LIQ significantly reduced cough frequency in the guinea pig models. Electrophysiological profiling revealed that LIQA suppressed human TRPA1 (hTRPA1) channel activity, while LIQ blocked human TRPV1 (hTRPV1) activation. High-resolution cryo-EM structures of hTRPA1/LIQA (2.59 Å) and hTRPV1/LIQ (3.05 Å) complexes were obtained. Structural analysis indicates that LIQA stabilizes hTRPA1 in a closed conformation with T624 at the coupling region site, whereas LIQ interacts with S512 through hydrogen bonding in the deep S4-S5 site of hTRPV1, thereby inhibiting pore opening. This study establishes LIQA and LIQ as lead compounds with acute antitussive activities mediated by TRPA1/TRPV1 modulation.
Money for the studygovernment, public institutions · National Natural Science Foundation of China
Do the authors have ties to companies?not stated
Did a manufacturer help with the study?unknown
Type of studyanimal study
“Not stated” does not mean nobody paid — the database does not always record it.
In mice, selected licorice compounds and extracts reduced cough, while some increased secretion that helps with expectoration.
Aim of the study: Licorice has been used as an antitussive and expectorant herbal medicine for a long history. This work evaluated the activities of 14 major compounds and crude extracts of licorice, using the classical ammonia-induced cough model and phenol red secretion model in mice.
Results: Moreover, compounds 1-3 showed potent expectorant activities after 3 days treatment (p < .05). The water and ethanol extracts of licorice, which contain abundant 1 and 2, could decrease cough frequency at 200 mg/kg by 25-59% (p < .05), and enhance the phenol red secretion (p < .05), while the ethyl acetate extract showed little effect. These results indicate liquiritin apioside and liquiritin are the major antitussive and expectorant compounds of licorice. Their antitussive effects depend on both peripheral and central mechanisms.
Money for the studygovernment, public institutions · National Natural Science Foundation of China
Do the authors have ties to companies?not stated
Did a manufacturer help with the study?unknown
Type of studyanimal study
“Not stated” does not mean nobody paid — the database does not always record it.
Licorice extract reduced citric acid-induced cough in guinea pigs.
Aim of the study: In the last decades plant substances have become a leading form of treatment of many respiratory symptoms, including cough. It has been shown that compounds purified form polysaccharides from Adhatoda vasica, Withania somnifera, and Glycyrrhiza glabra have various biological activities, such as antioxidant, anti-inflammatory, immunomodulating, antispasmodic action, or antiallergic properties, and they often act as cough suppressants.
Results: glabra. There was a 67% cough suppression with A. vasica and 61% with W. somnifera, which was comparable with the antitussive activity of codeine (62%).
Money for the studynot stated
Do the authors have ties to companies?not stated
Did a manufacturer help with the study?unknown
Type of studyanimal study
“Not stated” does not mean nobody paid — the database does not always record it.
In smokers, licorice lozenges were associated with less coughing after extubation than control candies.
Aim of the study: Post-Operative Sore Throat (POST) is an undesirable side effect ofendotracheal intubation. Pharmacological and non-pharmacological measures have been utilized for minimizing the morbidity caused by POST. We have tested whether medicated lozenges of Licorice provides efficacy in decreasing POST in smokers presenting for surgery under general anesthesia with endotracheal intubation.
Results: Overall incidence of postextubation cough was less in Group A (12 patients, 24%) compared to Group B (26 patients, 52%) (p = 0.002). Magnitude of sore throat (Grades 0/1/2/3) was seen in 48/2/0/0 patients (Group A) and 46/4/0/0 (Group B) at extubation (p = 0.40) and 34/16/0/0 patients (Group A) and 28/20/2/0 (Group B) at 30 min (p = 0.17). At 12 and 24 hours, the magnitudes of sore throats were 24/25/1/0 (Group A) & 12/38/0/0 (Group B) (p = 0.02) and 26/23/1/0 (Group A) & 15/35/0/0 (Group B) (p = 0.03) respectively. Use of licorice lozenges is efficacious for reducing the distressing complaint of POST in postoperative period among smokers.
Money for the studynot stated
Do the authors have ties to companies?not stated
Did a manufacturer help with the study?unknown
Type of studystudy with random allocation to groups (RCT)
Participants100
“Not stated” does not mean nobody paid — the database does not always record it.
A meta-analysis found that pre-intubation interventions, including licorice, reduced coughing after extubation.
Aim of the study: To evaluate the effectiveness of peri-intubation non-pharmacological interventions in reducing postoperative sore throat (POST), cough (PEC), and hoarseness in surgical patients.
Results: Nineteen trials with 2,136 participants were included. Pre-intubation intervention significantly reduced POST immediately after extubation (n = 861; OR: 0.28, 95 % CI: 0.20-0.38, P < 0.001), and 24 h post-extubation (n = 1006; OR: 0.21, 95 % CI: 0.16-0.28, P < 0.001). During-intubation intervention did not show significant effects on POST. Pre-intubation intervention also reduced POST-associated pain score at 24 h post-extubation (n = 440; MD: -0.50, 95 % CI: -0.81 to -0.18, P < 0.001). Post-intubation interventions were effective in reducing POST-associated pain scores at different time points post-extubation (P < 0.05). Pre-intubation intervention significantly reduced PEC (OR: 0.13, 95 % CI: 0.02-0.70, P = 0.02) and hoarseness (OR: 0.36, 95 %CI: 0.15-0.86, P = 0.02) at 24 h post-extubation. However, during-intubation interventions did not reduce hoarseness at 24 h post-extubation.
Money for the studyuniversity or foundation · Baqiyatallah University of Medical Sciences
Do the authors have ties to companies?not stated
Did a manufacturer help with the study?unknown
Type of studycombined analysis of many studies (meta-analysis)
“Not stated” does not mean nobody paid — the database does not always record it.
A syrup combining noscapine and licorice did not significantly improve the response to cough treatment compared with diphenhydramine.
Aim of the study: Background: As February 2023, SARS-CoV-2 is still infecting people and children worldwide. Cough and dyspnea are annoying symptoms almost present in a large proportion of COVID-19 outpatients, and the duration of these symptoms might be long enough to affect the patients' quality of life.
Results: The cough-related quality of life and severity also significantly favored Noscough® syrup (p-values <0.001). Conclusion: Noscapine plus licorice syrup was slightly superior to diphenhydramine in relieving cough symptoms and dyspnea in the COVID-19 outpatients. The severity of cough and cough-related quality of life were also significantly better in the noscapine plus licorice syrup. Noscapine plus licorice may be a valuable treatment in relieving cough in COVID-19 outpatients.
Money for the studynot stated
Do the authors have ties to companies?no — the authors say so
Did a manufacturer help with the study?NO
Type of studystudy with random allocation to groups (RCT)
Participants124
“Not stated” does not mean nobody paid — the database does not always record it.
Perspectives and opinion materials
The content below presents the authors’ opinions, interpretations and hypotheses. It is not treated as equal to scientific studies and systematic reviews.
Orthomolecular Medicine News Service Opinion material
„[6] In addition, a soothing licorice-based cough drop can help reduce irritation from a virus-caused sore throat. If the throat is uncomfortable due to postnasal drip, using a nasal spray followed by forceful clearing may help. It's important that the reader learn how to get the immune system to function at maximum strength in preparation for the next bout of infection. Taking a daily multivitamin along with vitamin C, D, and magnesium, is a good way to start.”[6] In addition, a soothing licorice-based cough drop can help reduce irritation from a virus-caused sore throat. If the throat is uncomfortable due to postnasal drip, using a nasal spray followed by forceful clearing may help. It's important that the reader learn how to get the immune system to function at maximum strength in preparation for the next bout of infection. Taking a daily multivitamin along with vitamin C, D, and magnesium, is a good way to start.
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